CAJ | 학술논문

目的：分析左氧氟沙星所致不良反应及临床合理用药。方法选取2013年9月—2014年9月进贤县人民医院收治的左氧氟沙星所致不良反应患者59例，对其临床资料进行回顾性分析。结果59例患者中21~60岁者50例（84.7%）；给药剂量200~400mg 有30例（50.8%）；静脉滴注51例（86.4%），口服7例（11.9%），滴眼1例（1.7%）；累及皮肤及其附件19例（32.2%），过敏性休克11例（18.6%），累及神经系统10例（16.9%）；停药后症状消失40例（67.8%），经糖皮质激素治疗康复10例（16.9%），对症治疗后康复9例（15.3%）。结论使用左氧氟沙星时必须严格掌握药物适应证，结合患者性别、年龄、给药剂量、给药途径等合理使用，以减少不良反应的发生。
목적：분석좌양불사성소치불량반응급림상합리용약。방법선취2013년9월—2014년9월진현현인민의원수치적좌양불사성소치불량반응환자59례，대기림상자료진행회고성분석。결과59례환자중21~60세자50례（84.7%）；급약제량200~400mg 유30례（50.8%）；정맥적주51례（86.4%），구복7례（11.9%），적안1례（1.7%）；루급피부급기부건19례（32.2%），과민성휴극11례（18.6%），루급신경계통10례（16.9%）；정약후증상소실40례（67.8%），경당피질격소치료강복10례（16.9%），대증치료후강복9례（15.3%）。결론사용좌양불사성시필수엄격장악약물괄응증，결합환자성별、년령、급약제량、급약도경등합리사용，이감소불량반응적발생。
Objective Analysis of adverse reactions caused by levofloxacin and clinical rational drug use. Methods A total of 59 cases with adverse reactions induced by levofloxacin were selected in the People's Hospital of Jinxian County from September 2013 to September 2014,the clinical data were retrospectively analyzed. Results 59 patients 21 ~ 60 years of age had 50 cases(84. 7% );dosage of administration 200 ~ 400mg had 30 cases(50. 8% );intravenous infusion 51 cases (86. 4% ),oral 7 cases(11. 9% ),eye drops 1 cases(1. 7% );involving the skin and its accessories 19 cases(32. 2% ), anaphylactic shock 11 cases(18. 6% ),central nervous system 10 cases(16. 9% );after drug withdrawal symptoms disap-peared 40 cases(67. 8% ),glucocorticoid therapy rehabilitated 10 cases(16. 9% ),rehabilitated after symptomatic treatment 9 cases(15. 3% ). Conclusion Levofloxacin indications must be mastered strictly when using drugs,combined with patient gender,age,dosage,drug dosing way such as fair use,which can reduce the occurrence of adverse reactions.