临床合理用药杂志
臨床閤理用藥雜誌
림상합리용약잡지
Chinese Journal of Clinical Rational Drug Use
2015年
30期
5-6
,共2页
食管肿瘤%老年人%XELOX 化疗%治疗结果
食管腫瘤%老年人%XELOX 化療%治療結果
식관종류%노년인%XELOX 화료%치료결과
Esophageal neoplasms%Aged%XELOX chemotherapy%Treatment outcome
目的：探讨 XELOX 化疗方案对老年食管癌晚期患者临床疗效及生存质量的影响。方法选取2013年3月—2014年3月赣州市肿瘤医院收治的老年食管癌晚期患者78例，随机分为观察组与对照组，各39例。观察组患者采用 XELOX 化疗方案化疗，对照组患者采用传统 PF 方案化疗。观察两组患者临床疗效、1年存活情况、治疗前后 Karnofsky（KPS）评分及毒副作用发生情况。结果观察组患者总有效率、1年存活率高于对照组，差异有统计学意义（P <0.05）；治疗前两组患者 KPS 评分比较，差异无统计学意义（P >0.05）；治疗后观察组患者 KPS 评分高于对照组，差异有统计学意义（P <0.05）；两组患者均未发生严重毒副作用。结论 XELOX 化疗方案对老年食管癌晚期患者临床疗效显著，可有效延长患者的存活时间，提高患者的生活质量，且毒副作用少。
目的：探討 XELOX 化療方案對老年食管癌晚期患者臨床療效及生存質量的影響。方法選取2013年3月—2014年3月贛州市腫瘤醫院收治的老年食管癌晚期患者78例，隨機分為觀察組與對照組，各39例。觀察組患者採用 XELOX 化療方案化療，對照組患者採用傳統 PF 方案化療。觀察兩組患者臨床療效、1年存活情況、治療前後 Karnofsky（KPS）評分及毒副作用髮生情況。結果觀察組患者總有效率、1年存活率高于對照組，差異有統計學意義（P <0.05）；治療前兩組患者 KPS 評分比較，差異無統計學意義（P >0.05）；治療後觀察組患者 KPS 評分高于對照組，差異有統計學意義（P <0.05）；兩組患者均未髮生嚴重毒副作用。結論 XELOX 化療方案對老年食管癌晚期患者臨床療效顯著，可有效延長患者的存活時間，提高患者的生活質量，且毒副作用少。
목적：탐토 XELOX 화료방안대노년식관암만기환자림상료효급생존질량적영향。방법선취2013년3월—2014년3월공주시종류의원수치적노년식관암만기환자78례，수궤분위관찰조여대조조，각39례。관찰조환자채용 XELOX 화료방안화료，대조조환자채용전통 PF 방안화료。관찰량조환자림상료효、1년존활정황、치료전후 Karnofsky（KPS）평분급독부작용발생정황。결과관찰조환자총유효솔、1년존활솔고우대조조，차이유통계학의의（P <0.05）；치료전량조환자 KPS 평분비교，차이무통계학의의（P >0.05）；치료후관찰조환자 KPS 평분고우대조조，차이유통계학의의（P <0.05）；량조환자균미발생엄중독부작용。결론 XELOX 화료방안대노년식관암만기환자림상료효현저，가유효연장환자적존활시간，제고환자적생활질량，차독부작용소。
Objective To explore the efficacy and the life quality effect of XELOX chemotherapy regimen on elderly patients with advanced esophageal carcinoma. Methods A total of 78 elderly patients with advanced esophageal carcinoma were selected in the Tumor Hospital of Ganzhou from March 2013 to March 2014,they were randomly divided into control group and observation group,39 cases in each group. Observation group were given XELOX chemotherapy regimen treatment,control group were given traditional PF chemotherapy. Clinical effect,one year survival situation,before and after treatment Karnofsky(KPS) scores and incidence condition of side effect between the two groups were compared. Results The total effective rate,one year survival rate of observation group were higher than those of control group(P < 0. 05);before treatment,KPS scores showed no significant differences between the two groups(P > 0. 05),after treatment,KPS scores of observation group wase higher than that of control group(P < 0. 05);two groups had no side effect during treatment. Conclusion XELOX chemotherapy regimen has notable curative effect in the treatment of elderly patients with advanced esophageal carcinoma,can effectively prolong the survival time of patients,improve the quality of life of patients,and have less side effects.
