北京中医药大学学报
北京中醫藥大學學報
북경중의약대학학보
Journal of Beijing University of Traditional Chinese Medicine
2015年
10期
703-708,715,725
,共8页
巴寅颖%姜艳艳%吴霞%石任兵
巴寅穎%薑豔豔%吳霞%石任兵
파인영%강염염%오하%석임병
开心散%远志%西伯利亚远志糖A5%西伯利亚远志糖A6%药动学%药物属性
開心散%遠誌%西伯利亞遠誌糖A5%西伯利亞遠誌糖A6%藥動學%藥物屬性
개심산%원지%서백리아원지당A5%서백리아원지당A6%약동학%약물속성
Kaixin San%Polygala tenuifolia wild%sibiricose A5%sibiricose A6%pharmacokinetic%drug properties
目的 在记忆障碍模型大鼠下,对比分析单体(西伯利亚远志糖A5和西伯利亚远志糖A6 )、单味药(远志)和复方(开心散)3个层次的药动学特性及其相互作用性( PK-DI) ,考量远志与复方在治疗痴呆中的药物属性. 方法 采用HPLC-PDA 同时测定给药后记忆障碍模型大鼠体内西伯利亚远志糖A5和西伯利亚远志糖A6 血药浓度,获得各药物体内药代动力学表征数据, kinetics 4 .4软件处理数据. 采用PK-DI 关联分析法对比分析不同药物形式的特性表征. 结果 西伯利亚远志糖A5和西伯利亚远志糖A6药-时曲线均使用非房室模型处理. 远志和开心散药代动力学表征相似,均呈现双峰吸收,而西伯利亚远志糖A5和西伯利亚远志糖A6单体药代动力学表征发生明显改变,呈单峰吸收. 西伯利亚远志糖A5和西伯利亚远志糖A6的AUC值在远志组和开心散组间无明显差异,均远远大于单体组( P<0.01). 而与单味药远志相比,开心散复方药物状态下的最大血药浓度大幅增加(P<0.05). 结论 与单体相比,单味药远志和开心散复方的药代动力学表征发生了改变,生物利用度大幅提高,且复方配伍后更是增大了药物作用强度,表征出复方药物协同作用特性,从而展示出了复方具有其药物属性特性.
目的 在記憶障礙模型大鼠下,對比分析單體(西伯利亞遠誌糖A5和西伯利亞遠誌糖A6 )、單味藥(遠誌)和複方(開心散)3箇層次的藥動學特性及其相互作用性( PK-DI) ,攷量遠誌與複方在治療癡呆中的藥物屬性. 方法 採用HPLC-PDA 同時測定給藥後記憶障礙模型大鼠體內西伯利亞遠誌糖A5和西伯利亞遠誌糖A6 血藥濃度,穫得各藥物體內藥代動力學錶徵數據, kinetics 4 .4軟件處理數據. 採用PK-DI 關聯分析法對比分析不同藥物形式的特性錶徵. 結果 西伯利亞遠誌糖A5和西伯利亞遠誌糖A6藥-時麯線均使用非房室模型處理. 遠誌和開心散藥代動力學錶徵相似,均呈現雙峰吸收,而西伯利亞遠誌糖A5和西伯利亞遠誌糖A6單體藥代動力學錶徵髮生明顯改變,呈單峰吸收. 西伯利亞遠誌糖A5和西伯利亞遠誌糖A6的AUC值在遠誌組和開心散組間無明顯差異,均遠遠大于單體組( P<0.01). 而與單味藥遠誌相比,開心散複方藥物狀態下的最大血藥濃度大幅增加(P<0.05). 結論 與單體相比,單味藥遠誌和開心散複方的藥代動力學錶徵髮生瞭改變,生物利用度大幅提高,且複方配伍後更是增大瞭藥物作用彊度,錶徵齣複方藥物協同作用特性,從而展示齣瞭複方具有其藥物屬性特性.
목적 재기억장애모형대서하,대비분석단체(서백리아원지당A5화서백리아원지당A6 )、단미약(원지)화복방(개심산)3개층차적약동학특성급기상호작용성( PK-DI) ,고량원지여복방재치료치태중적약물속성. 방법 채용HPLC-PDA 동시측정급약후기억장애모형대서체내서백리아원지당A5화서백리아원지당A6 혈약농도,획득각약물체내약대동역학표정수거, kinetics 4 .4연건처리수거. 채용PK-DI 관련분석법대비분석불동약물형식적특성표정. 결과 서백리아원지당A5화서백리아원지당A6약-시곡선균사용비방실모형처리. 원지화개심산약대동역학표정상사,균정현쌍봉흡수,이서백리아원지당A5화서백리아원지당A6단체약대동역학표정발생명현개변,정단봉흡수. 서백리아원지당A5화서백리아원지당A6적AUC치재원지조화개심산조간무명현차이,균원원대우단체조( P<0.01). 이여단미약원지상비,개심산복방약물상태하적최대혈약농도대폭증가(P<0.05). 결론 여단체상비,단미약원지화개심산복방적약대동역학표정발생료개변,생물이용도대폭제고,차복방배오후경시증대료약물작용강도,표정출복방약물협동작용특성,종이전시출료복방구유기약물속성특성.
Objective To study anti-dementia effects of Kaixin San ( Joyful Powder ) and Radix Polygalae's based on pharmacokinetic characteristics of sibiricose A5, sibiricose A6, 3,6'-disinapoyl sucrose, and polygala xanthone Ⅲ in rats with acquired dysmnesia model from three levels: monomer,medicinal and formula.Method Serum concentrations of sibiricose A5 and sibiricose A6 after oral administration in rat model were measured by using HPLC-PDA Pharmacokinetic data were obtained. Then different forms of sibiricose A5 and A6 were compared with correlation analysis ( PK-DI ) . Result Concentration-time curves showed that the pharmacokinetic profiles were similar in the absorption phase when Radix Polygalae extract and Kaixin San were orally administered.A bimodal patternof sibiricose A5 and A6 in the serum profile was revealed.However, this phenomenon was not observed in the group of monomer.Radix Polygalae extracts and Kaixin San were similar in the measurements of AUC, and levels of monomer were decreased significantly (P<0.01).Compared to the oral administration of Radix Polygalae extract, Cmax-1 and Cmax-2 of Kaixin San were increased significantly ( P<0.05) .Conclution The results showed that the absorption of sibiricose A5 and A6 in rats was superior when Kaixin San was administered.This finding supports the rationale for using the Kaixin San combination in clinical use.
