临床合理用药杂志
臨床閤理用藥雜誌
림상합리용약잡지
Chinese Journal of Clinical Rational Drug Use
2015年
31期
9-10
,共2页
泮托拉唑%奥美拉唑%质子泵抑制剂%胃炎
泮託拉唑%奧美拉唑%質子泵抑製劑%胃炎
반탁랍서%오미랍서%질자빙억제제%위염
Pantoprazole%Omeprazole%Proton pump inhibitor%Gastritis
目的：观察泮托拉唑在临床中应用的安全性，以提高第三代质子泵抑制剂药物的临床应用水平。方法选取服用泮托拉唑的胃炎患者2500例和服用奥美拉唑的胃炎患者2500例，观察2组药物不良反应发生情况、老年患者的不良反应发生率、长期治疗患者的不良反应发生率。结果泮托拉唑组不良反应的发生率低于奥美拉唑组（P ＜0．05）；老年患者的不良反应发生率不高于年轻患者；长期服药患者的不良反应未见增高。结论泮托拉唑可以安全高效快速抑制胃酸分泌，值得临床推广应用。
目的：觀察泮託拉唑在臨床中應用的安全性，以提高第三代質子泵抑製劑藥物的臨床應用水平。方法選取服用泮託拉唑的胃炎患者2500例和服用奧美拉唑的胃炎患者2500例，觀察2組藥物不良反應髮生情況、老年患者的不良反應髮生率、長期治療患者的不良反應髮生率。結果泮託拉唑組不良反應的髮生率低于奧美拉唑組（P ＜0．05）；老年患者的不良反應髮生率不高于年輕患者；長期服藥患者的不良反應未見增高。結論泮託拉唑可以安全高效快速抑製胃痠分泌，值得臨床推廣應用。
목적：관찰반탁랍서재림상중응용적안전성，이제고제삼대질자빙억제제약물적림상응용수평。방법선취복용반탁랍서적위염환자2500례화복용오미랍서적위염환자2500례，관찰2조약물불량반응발생정황、노년환자적불량반응발생솔、장기치료환자적불량반응발생솔。결과반탁랍서조불량반응적발생솔저우오미랍서조（P ＜0．05）；노년환자적불량반응발생솔불고우년경환자；장기복약환자적불량반응미견증고。결론반탁랍서가이안전고효쾌속억제위산분비，치득림상추엄응용。
Objective Through the investigation of safety evaluation of pantoprazole in the clinical application,im-prove the level of clinical application of the third generation of proton pump inhibitor drugs.Methods 2500 gastritis patients with taking pantoprazole and 2500 gastritis patients with taking omeprazole in our hospital were selected.The adverse drug re-action occurred,adverse reaction rate of elderly patients,adverse reaction incidence of long-term treatment patients were ob-served.Results The incidence of pantoprazole adverse reaction rate was lower than omeprazole (P <0.05);the incidence of elderly patients not higher than in younger patients;adverse events of long term treatment patients were not increased.Conclu-sion Pantoprazole can safely and efficiently inhibit gastric acid secretion,and it is worthy of clinical application.
