临床合理用药杂志
臨床閤理用藥雜誌
림상합리용약잡지
Chinese Journal of Clinical Rational Drug Use
2015年
30期
38-39
,共2页
胃肿瘤%多西他赛%氟尿嘧啶%药物疗法,联合
胃腫瘤%多西他賽%氟尿嘧啶%藥物療法,聯閤
위종류%다서타새%불뇨밀정%약물요법,연합
Stomach neoplasms%Docetaxel%Fluorouracil%Drug therapy,combination
目的：探讨多西他赛联合5氟尿嘧啶（5- Fu）治疗进展期胃癌的疗效。方法选取2009年1月—2011年1月南京医科大学附属江宁医院肿瘤内科收治的50例进展期胃癌患者，应用多西他赛、5- Fu 化疗，化疗有效者至少治疗4~6个化疗周期或一直治疗至病情进展（PD）为止。结果50例患者中46例（92.0%）可以评价客观疗效，总缓解率为48.0%。白细胞计数下降发生率为20.0%；血小板计数降低发生率为10.0%，无需血小板输注。此外，有20.0%患者出现轻度静脉炎。50例患者经积极处理好转，未见严重的全身感染和治疗相关死亡。结论多西他赛联合顺铂和5- Fu 治疗进展期胃癌有效，毒副作用可耐受，临床使用安全。
目的：探討多西他賽聯閤5氟尿嘧啶（5- Fu）治療進展期胃癌的療效。方法選取2009年1月—2011年1月南京醫科大學附屬江寧醫院腫瘤內科收治的50例進展期胃癌患者，應用多西他賽、5- Fu 化療，化療有效者至少治療4~6箇化療週期或一直治療至病情進展（PD）為止。結果50例患者中46例（92.0%）可以評價客觀療效，總緩解率為48.0%。白細胞計數下降髮生率為20.0%；血小闆計數降低髮生率為10.0%，無需血小闆輸註。此外，有20.0%患者齣現輕度靜脈炎。50例患者經積極處理好轉，未見嚴重的全身感染和治療相關死亡。結論多西他賽聯閤順鉑和5- Fu 治療進展期胃癌有效，毒副作用可耐受，臨床使用安全。
목적：탐토다서타새연합5불뇨밀정（5- Fu）치료진전기위암적료효。방법선취2009년1월—2011년1월남경의과대학부속강저의원종류내과수치적50례진전기위암환자，응용다서타새、5- Fu 화료，화료유효자지소치료4~6개화료주기혹일직치료지병정진전（PD）위지。결과50례환자중46례（92.0%）가이평개객관료효，총완해솔위48.0%。백세포계수하강발생솔위20.0%；혈소판계수강저발생솔위10.0%，무수혈소판수주。차외，유20.0%환자출현경도정맥염。50례환자경적겁처리호전，미견엄중적전신감염화치료상관사망。결론다서타새연합순박화5- Fu 치료진전기위암유효，독부작용가내수，림상사용안전。
Objective To investigate the effect of docetaxel combined with fluorouracil(5 - Fu)in treating advanced gastric cancer. Methods From January 2009 to January 2011 in the Affiliated Jiangning Hospital of Nanjing Medical Universi-ty,50 advanced gastric cancer patients were selected,they were treated with docetaxel 5 - Fu chemotherapy,effective by at least four to six courses or to disease progression(PD). Results In 50 patients,46 cases(92. 0% )could evaluate objective response,overall response rate was 48. 0%. White blood cell count decreased incidence was 20. 0% ;incidence of thrombocyto-penia was 10. 0% ,and they were without platelet transfusion. In addition,20. 0% of patients had mild phlebitis. 50 patients im-proved after active treatment,no serious systemic infections and treatment - related deaths. Conclusion Docetaxel combined with 5 - Fu have effect in the treatment of advanced gastric cancer,side effects can be tolerated,it's safe in clinical using.
