CAJ | 학술논문

目的：探讨水通道蛋白5(AQP5)的表达与结直肠癌临床病理及预后关系。方法收集术前未予任何治疗的临床病例资料齐全的原发性结直肠癌病例45例,采用免疫组化法检测 AQP5的表达。比较 AQP5表达与年龄、肿瘤大小、临床分期、肿瘤部位、淋巴结、病理类型之间的关系,并结合随访资料分析 AQP5表达与否和预后的关系。结果45个肿瘤标本中,14例(31.1%)高表达 AQP5,29例(64.4%)中度表达,2例(4.4%)无 AQP5染色。癌旁和正常组织中 AQP5表达率分别为3例(6.67%)和3例(6.67%)。AQP5的表达还与 TNM 分期(P =0.002)、淋巴结转移(P =0.016)、远处转移(P =0.000)呈正相关。在年龄、性别、组织学分级和肿瘤大小中其表达没有统计学差异(P >0.05)。结论AQP5可能被用作预测结直肠癌预后的良好指标。
목적：탐토수통도단백5(AQP5)적표체여결직장암림상병리급예후관계。방법수집술전미여임하치료적림상병례자료제전적원발성결직장암병례45례,채용면역조화법검측 AQP5적표체。비교 AQP5표체여년령、종류대소、림상분기、종류부위、림파결、병리류형지간적관계,병결합수방자료분석 AQP5표체여부화예후적관계。결과45개종류표본중,14례(31.1%)고표체 AQP5,29례(64.4%)중도표체,2례(4.4%)무 AQP5염색。암방화정상조직중 AQP5표체솔분별위3례(6.67%)화3례(6.67%)。AQP5적표체환여 TNM 분기(P =0.002)、림파결전이(P =0.016)、원처전이(P =0.000)정정상관。재년령、성별、조직학분급화종류대소중기표체몰유통계학차이(P >0.05)。결론AQP5가능피용작예측결직장암예후적량호지표。
Objective To determine the relationship of the expression of aquaporin 5 (AQP5)with clinicopathology and prognosis of colorectal cancer.Methods We collected data from 45 patients with primary colorectal cancer without any adjuvant therapy before operation.The expression of AQP5 was measured by immunohistochemistry (IHC).Then we analyzed the correlation between AQP5 expression and clinicopathological parameters (including age,tumor size,clinical staging,tumor location,lymph node and pathological type)and the connection between AQP5 expression and prognosis based on follow-up data.Results Of the 45 tumor specimens,14 (31.1%)had a high level of AQP5 expression,29 (64.4%)exhibited a moderate level of staining,and 2 (4.4%)had an absence of AQP5 staining.AQP5 was only occasionally detected in para-neoplastic [3/45 (6.67%)]and normal tissues [3/45 (6.67%)].The overexpression of AQP5 was also positively associated with TNM stage (P =0.002),lymph node metastasis (P =0.01 6),and distant metastasis (P =0.000).However,it had no significant association with age, gender,histologic grade or tumor size (P > 0.05 ).Conclusion AQP5 may be used as a novel biomarker for predicting the prognosis of colorectal cancer.