CAJ | 학술논문

目的：探讨2型糖尿病合并脑病的中医证候要素、靶位，以及理化指标与中医证候之间的关系。方法收集中国中医科学院广安门医院，北京中医药大学东直门医院、东方医院等九家医院约3年的2501例2型糖尿病患者的相关数据。对原始资料进行双人双机 epidata 录入，建立 Excel 数据库，选取342例2型糖尿病合并脑病患者的病历，采用因子分析和贝叶斯网络的方法进行数据挖掘。结果通过因子分析得出20个特征根大于1的因素，占总特征根的68.4%，其中5个因素属阴虚、5个因素属血瘀；通过贝叶斯网络得出空腹血糖异常者主要症状是倦怠乏力、气短懒言、大便频多；餐后2小时血糖异常者主要症状倦怠乏力、半身不遂；糖化血红蛋白异常者主要症状倦怠乏力、五心烦热、大便频多、夜尿频多。结论糖尿病合并脑病的证候要素是阴虚、血瘀；主要靶位是肝、肾、脾。空腹血糖异常者中医证候以气虚为主；餐后2 h 血糖异常患者的中医证候是气虚或风中脉络；糖化血红蛋白异常的患者，中医证型以气虚、阴虚常见。
목적：탐토2형당뇨병합병뇌병적중의증후요소、파위，이급이화지표여중의증후지간적관계。방법수집중국중의과학원엄안문의원，북경중의약대학동직문의원、동방의원등구가의원약3년적2501례2형당뇨병환자적상관수거。대원시자료진행쌍인쌍궤 epidata 록입，건립 Excel 수거고，선취342례2형당뇨병합병뇌병환자적병력，채용인자분석화패협사망락적방법진행수거알굴。결과통과인자분석득출20개특정근대우1적인소，점총특정근적68.4%，기중5개인소속음허、5개인소속혈어；통과패협사망락득출공복혈당이상자주요증상시권태핍력、기단라언、대편빈다；찬후2소시혈당이상자주요증상권태핍력、반신불수；당화혈홍단백이상자주요증상권태핍력、오심번열、대편빈다、야뇨빈다。결론당뇨병합병뇌병적증후요소시음허、혈어；주요파위시간、신、비。공복혈당이상자중의증후이기허위주；찬후2 h 혈당이상환자적중의증후시기허혹풍중맥락；당화혈홍단백이상적환자，중의증형이기허、음허상견。
Objective To explore characteristics of the elements of syndrome, the disease position and the relationship between chemical indicators and TCM syndromes of type 2 diabetic encephalopathy. Methods 2 501 cases of type 2 diabetes clinical data were collected from Guang'anmen Hospital of China Academy of Chinese Medical Sciences, Beijing University of Chinese Medicine, Dongzhimen Hospital, Dongfang Hospital, etc. in nearly 3 years, among which, 342 cases were type 2 diabetic encephalopathy. The original clinical data were double entried in epidata by two people, establishment forms in excel, factor analysis and Bayesian networks were used as data mining research methods. Results 20 elements which characteristic root more than 1 were derived by factor analysis, 68.4% were covered. Of all 20 elements, five factors belong to Yin, five factors belong to blood stasis; lassitude, shortness of breath, stool frequency were appeared when fasting glucose abnormalities; lassitude, hemiplegia were appeared when 2-hour postprandial blood glucose abnormalities;lassitude, feverish palms and soles, stool frequency, more nocturnal enuresis when glycated hemoglobin abnormalities by Bayesian networks. Conclusion The Elements of the syndrome of type 2 diabetes encephalopathy were deficiency of Yin and blood stasis; and the main positions for diabetic patients were liver, spleen and kidney. Patients with impaired fasting glucose were Qi deficiency; Patients with impaired 2-hour postprandial glucose were Qi deficiency or pathogenic wind attacking collaterals; Patients with abnormal hemoglobin were Qi deficiency and Yin deficiency.