CAJ | 학술논문

目的：探讨多回波快速自旋回波序列（ MEFSE）的T2 mapping定量技术评价左室心肌T2值的价值。方法30例健康志愿者，均行3．0T心脏磁共振（CMR）Cine电影、T2WI序列、MEFSE T2 mapping序列扫描，依据描述性研究方法，探索MEFSE T2 mapping序列临床应用的可行性和可重复性，测定感兴趣区T2值，应用方差分析方法统计分析心肌17节段和不同供血区下有无差异。应用Bland～Altman分析和Pearson相关分析方法研究此技术在不同观察者间的一致性。结果健康志愿者17节段心肌T2值不全相等（P＜0．01）。不同冠状动脉供血区T2值无统计学差异（F＝1．656，P＝0．192）。左室心肌平均T2值如下：基底部，（71．6±7．1）ms；中间部，（77．3±9．2） ms；心尖部，（83．0±8．5）ms，差异有统计学意义（F＝14．245， P＜0．01）。根据Bland-Altman一致性分析和Pearson相关分析得到参数测量在观察者间具有良好的一致性，95％一致性界限（－6．1，24．8）ms，相关系数r＝0．809。结论 CMR MEFSE T2 mapping定量技术在心脏成像中具有较好的可行性和可重复性。中国健康志愿者中心肌T2值存在节段性差异。
목적：탐토다회파쾌속자선회파서렬（ MEFSE）적T2 mapping정량기술평개좌실심기T2치적개치。방법30례건강지원자，균행3．0T심장자공진（CMR）Cine전영、T2WI서렬、MEFSE T2 mapping서렬소묘，의거묘술성연구방법，탐색MEFSE T2 mapping서렬림상응용적가행성화가중복성，측정감흥취구T2치，응용방차분석방법통계분석심기17절단화불동공혈구하유무차이。응용Bland～Altman분석화Pearson상관분석방법연구차기술재불동관찰자간적일치성。결과건강지원자17절단심기T2치불전상등（P＜0．01）。불동관상동맥공혈구T2치무통계학차이（F＝1．656，P＝0．192）。좌실심기평균T2치여하：기저부，（71．6±7．1）ms；중간부，（77．3±9．2） ms；심첨부，（83．0±8．5）ms，차이유통계학의의（F＝14．245， P＜0．01）。근거Bland-Altman일치성분석화Pearson상관분석득도삼수측량재관찰자간구유량호적일치성，95％일치성계한（－6．1，24．8）ms，상관계수r＝0．809。결론 CMR MEFSE T2 mapping정량기술재심장성상중구유교호적가행성화가중복성。중국건강지원자중심기T2치존재절단성차이。
Objective To investigate the clinical feasibility and repeatability of a quantitative T 2 mapping technique by multi-echo fast spin-echo (MEFSE), and to evaluate the left ventricular myocardial T 2 values in different segments.Methods With a 3.0T magnetic resonance (MR) imaging system, according to descriptive research method, cardiovascular magnetic imaging(CMR)was per-formed in 30 healthy volunteers to investigate the clinical feasibility and repeatability of the quantitative MEFSE T 2 mapping technique , combined with Cine and T2WI.T2 values in 17 segments of myocardium and different blood supply areas were measured and compared using one-way ANOVA.The agreement of two radiologists was evaluated by Bland-Altman method and Pearsosn correlation analysis . Results There were differences in the T2 values between some of 17 segmental myocardia (P<0.01).T2 values were similar in dif-ferent blood supply areas (F=1.656, P=0.192).Mean myocardial T2 values from the base to the apex were different (F=14.245, P<0.01):(71.6 ±7.1) ms (base), (77.3 ±9.2) ms (middle), (83.0 ±8.5)ms(apex).According to the Bland—Altman meth-od and Pearson correlation analysis , the measurement of T 2 values had a good inter-observer agreement [ 95% limits of agreement (-6.1,24.8) ms, correlation coefficient r=0.809].Conclusions Quantitative CMR MEFSE T2mapping technology is feasible and repeatable .Myocardial T 2 reference values for the specific CMR setting are provided and they have regional variation .