CAJ | 학술논문

目的：观察雷公藤多苷联合羟苯磺酸钙治疗糖尿病肾病的临床疗效。方法将52例糖尿病肾病患者分为治疗组和对照组，对照组在常规治疗基础上加用雷公藤多苷片，治疗组在常规治疗基础上给予雷公藤多苷片联合羟苯磺酸钙片。观察治疗前后2组丙氨酸转氨酶、血清白蛋白、血肌酐、白细胞、24 h尿蛋白定量等指标的变化。结果2组治疗前后血清白蛋白、血肌酐、24 h尿蛋白水平比较差异具有统计学意义（P<0.05），治疗组与对照组治疗后比较差异具有统计学意义（P<0.05）。结论两种治疗方法对糖尿病肾病均有效，雷公藤多苷片联合羟苯磺酸钙片效果更好。
목적：관찰뢰공등다감연합간분광산개치료당뇨병신병적림상료효。방법장52례당뇨병신병환자분위치료조화대조조，대조조재상규치료기출상가용뢰공등다감편，치료조재상규치료기출상급여뢰공등다감편연합간분광산개편。관찰치료전후2조병안산전안매、혈청백단백、혈기항、백세포、24 h뇨단백정량등지표적변화。결과2조치료전후혈청백단백、혈기항、24 h뇨단백수평비교차이구유통계학의의（P<0.05），치료조여대조조치료후비교차이구유통계학의의（P<0.05）。결론량충치료방법대당뇨병신병균유효，뢰공등다감편연합간분광산개편효과경호。
Objective To observe the clinical effect of tripterygium glycosides combined with calcium dobesilate in diabetic nephropathy.Methods 52 cases patients with diabetic nephropathy were randomly divided into treatment group (24 cases) and control group (28 cases). On the basis of conventional treatment,Control group were given tripterygium glycosides,treatment group were given tripterygium glycosides combined with calcium dobesilate. Compared the level of alanine aminotransferase,serum albumin,serum creatinine,white blood cells and 24 hours urine protein before and after treatment between the tow groups.Results The difference of serum albumin,serum creatinine and 24 hours urine protein were statistically significant before and after treatment in the two groups(P<0.05). The levels of serum albumin,serum creatinine and 24 hours urine protein between the two group after treatment had difference,the difference were statistically significant (P<0.05).Conclusion The treatments in the two groups were effective. Using tripterygium glycosides combined with calcium dobesilate was better than using tripterygium glycosides singly in diabetic nephropathy .