西北药学杂志
西北藥學雜誌
서북약학잡지
Northwest Pharmaceutical Journal
2015年
6期
728-732
,共5页
邓梓辛%张美祥%谭璐%汪曲%王树平
鄧梓辛%張美祥%譚璐%汪麯%王樹平
산재신%장미상%담로%왕곡%왕수평
溴己新%氨溴索%慢性支气管炎%M eta分析
溴己新%氨溴索%慢性支氣管炎%M eta分析
추기신%안추색%만성지기관염%M eta분석
bromhexine%ambroxol%chronic bronchitis%Meta-analysis
目的:评价溴己新治疗慢性支气管炎的疗效及安全性。方法通过检索PubMed、Cochrane library、中国期刊全文数据库(China National Knowledge Internet ,CNKI)、维普数据库(Weip Database ,VIP)和万方数字化期刊全文数据库;纳入随机对照试验(Randomized Controlled Trial ,RCT)8篇,包括溴己新对比氨溴索、二陈汤、咳喘宁口服液、S‐羧甲半胱氨酸和安慰剂组;利用Jadad质量评分工具进行方法质量评价。结果溴己新组对比氨溴索组共4个RC T ,临床总有效率比较:R R=0.83,95% C I (0.76,0.91),P<0.0001,差异有统计学意义。其余组由于文献数量少限制而进行描述性分析。结论溴己新可以有效地治疗慢性支气管炎,但是质量评分以及Meta分析显示其疗效低于氨溴索。
目的:評價溴己新治療慢性支氣管炎的療效及安全性。方法通過檢索PubMed、Cochrane library、中國期刊全文數據庫(China National Knowledge Internet ,CNKI)、維普數據庫(Weip Database ,VIP)和萬方數字化期刊全文數據庫;納入隨機對照試驗(Randomized Controlled Trial ,RCT)8篇,包括溴己新對比氨溴索、二陳湯、咳喘寧口服液、S‐羧甲半胱氨痠和安慰劑組;利用Jadad質量評分工具進行方法質量評價。結果溴己新組對比氨溴索組共4箇RC T ,臨床總有效率比較:R R=0.83,95% C I (0.76,0.91),P<0.0001,差異有統計學意義。其餘組由于文獻數量少限製而進行描述性分析。結論溴己新可以有效地治療慢性支氣管炎,但是質量評分以及Meta分析顯示其療效低于氨溴索。
목적:평개추기신치료만성지기관염적료효급안전성。방법통과검색PubMed、Cochrane library、중국기간전문수거고(China National Knowledge Internet ,CNKI)、유보수거고(Weip Database ,VIP)화만방수자화기간전문수거고;납입수궤대조시험(Randomized Controlled Trial ,RCT)8편,포괄추기신대비안추색、이진탕、해천저구복액、S‐최갑반광안산화안위제조;이용Jadad질량평분공구진행방법질량평개。결과추기신조대비안추색조공4개RC T ,림상총유효솔비교:R R=0.83,95% C I (0.76,0.91),P<0.0001,차이유통계학의의。기여조유우문헌수량소한제이진행묘술성분석。결론추기신가이유효지치료만성지기관염,단시질량평분이급Meta분석현시기료효저우안추색。
Objective To assess the effect and safety of bromhexine for chronic bronchitis .Methods We retrieve the database inclu‐ding PubMed ,the Cochrane library ,China National Knowledge Internet (CNKI) ,Weip Database (VIP) and Wanfang Data . Eight randomized controlled trials (RCT ) comparing bromhexine with ambroxol ,Erchentang ,Kechuanning oral liquid ,S‐carboxy‐methylcysteine and placebo were included in this research .The course of treatment was more than 5 days .The Jadad quality tools was used for the quality evaluation of each study .Results There were 4 RCTs which compared bromhexine with ambroxol ,with significant difference in clinical overall efficacy [RR=0 .83 ,95% CI(0 .76 ,0 .91) ,P<0 .000 1] .The rest groups required descrip‐tive analysis for study quantity .Conclusion Chronic bronchitis can be treated effectively by bromhexine .However ,compared with ambroxol ,the result of quality grade and Meta‐analysis reveals lower curative effect .