西北药学杂志
西北藥學雜誌
서북약학잡지
Northwest Pharmaceutical Journal
2015年
6期
740-743
,共4页
氨溴索%珂立苏%呼吸窘迫综合征%早产儿
氨溴索%珂立囌%呼吸窘迫綜閤徵%早產兒
안추색%가립소%호흡군박종합정%조산인
ambroxol%calsurf%neonatal respiratory distress syndrome%premature infants
目的：探讨氨溴索联合珂立苏（牛肺表面活性剂）对早产新生儿呼吸窘迫综合征（NRDS）的治疗疗效。方法将85例诊断为NRDS患儿随机分成试验组43例和对照组42例。在采取机械通气等常规治疗方法的基础上，试验组加用氨溴索联合珂立苏治疗，对照组仅加用珂立苏治疗，连续用药4d，比较2组疗效。结果2组患儿的病情均有所改善，试验组治疗效果更佳。试验组患儿血气指标PaO2、PaCO2、pH、好转时间较对照组快（P＜0．05）；治疗后X线胸片评分均下降，试验组治疗疗效明显优于对照组（ P＜0．001）；试验组机械通气时间、住院时间明显短于对照组（ P＜0．001）。结论氨溴索联合珂立苏能明显改善早产儿呼吸窘迫综合征患儿的缺氧情况，预后良好，能有效减少机械通气时间与住院时间。
目的：探討氨溴索聯閤珂立囌（牛肺錶麵活性劑）對早產新生兒呼吸窘迫綜閤徵（NRDS）的治療療效。方法將85例診斷為NRDS患兒隨機分成試驗組43例和對照組42例。在採取機械通氣等常規治療方法的基礎上，試驗組加用氨溴索聯閤珂立囌治療，對照組僅加用珂立囌治療，連續用藥4d，比較2組療效。結果2組患兒的病情均有所改善，試驗組治療效果更佳。試驗組患兒血氣指標PaO2、PaCO2、pH、好轉時間較對照組快（P＜0．05）；治療後X線胸片評分均下降，試驗組治療療效明顯優于對照組（ P＜0．001）；試驗組機械通氣時間、住院時間明顯短于對照組（ P＜0．001）。結論氨溴索聯閤珂立囌能明顯改善早產兒呼吸窘迫綜閤徵患兒的缺氧情況，預後良好，能有效減少機械通氣時間與住院時間。
목적：탐토안추색연합가립소（우폐표면활성제）대조산신생인호흡군박종합정（NRDS）적치료료효。방법장85례진단위NRDS환인수궤분성시험조43례화대조조42례。재채취궤계통기등상규치료방법적기출상，시험조가용안추색연합가립소치료，대조조부가용가립소치료，련속용약4d，비교2조료효。결과2조환인적병정균유소개선，시험조치료효과경가。시험조환인혈기지표PaO2、PaCO2、pH、호전시간교대조조쾌（P＜0．05）；치료후X선흉편평분균하강，시험조치료료효명현우우대조조（ P＜0．001）；시험조궤계통기시간、주원시간명현단우대조조（ P＜0．001）。결론안추색연합가립소능명현개선조산인호흡군박종합정환인적결양정황，예후량호，능유효감소궤계통기시간여주원시간。
Objective To investigate the effect of ambroxol with pulmonary surfactant (PS)‐calsurf in the treatment of 85 premature infants with neonatal respiratory distress syndrome .Methods 85 cases of children diagnosed with NRDS were randomly divided into experimental group (n=43) and the control group (n=42) .In addition to conventional treatments such as mechanical venti‐lation ,the experimental group were treated with ambroxol and calsurf ,while the control group were only treated with calsurf therapy .After 4 day’s continuous medication ,the treatment effect was compared .Results Both groups of patients had diseases remission and the experimental treatment group got better treatment effect .Blood gas analysis criteria of PaO2 ,PaCO2 ,and pH of the experimental group improved faster than the control group(P<0 .05);After treatment ,the experimental group were signifi‐cantly better than the control group(P<0 .001);The duration of mechanical ventilation and length of hospital stay of the experi‐mental group were significantly less than the control group(P<0 .001) .Conclusion Ambroxol with pulmonary surfactant (PS)‐calsurf could significantly improve the situation of premature infants with respiratory distress syndrome ,and the therapeutic meth‐od can effectively reduce the duration of mechanical ventilation and the length of hospital stay with good prognosis .
