解放军医药杂志
解放軍醫藥雜誌
해방군의약잡지
Medical & Pharmaceutical Journal of Chinese People's Liberation Army
2015年
10期
94-99
,共6页
胃肿瘤%肠道营养%四君子汤%精氨酸%营养状况%免疫调节
胃腫瘤%腸道營養%四君子湯%精氨痠%營養狀況%免疫調節
위종류%장도영양%사군자탕%정안산%영양상황%면역조절
Stomach neoplasms%Enteral nutrition%Sijunzi decoction%Arginine%Nutritional Status%Immuno-modulation
目的 探讨四君子汤联合精氨酸对胃癌术后营养状态及免疫功能的影响. 方法 2010年4月—2014年10月收治的晚期胃癌100例,随机分为观察组和对照组,每组50例,两组均术后早期给予肠内营养支持,观察组在此基础上加用四君子汤与精氨酸,观察两组术后营养指标及免疫功能情况. 结果 两组患者术后8d血红蛋白、总胆固醇、甘油三酯、低密度脂蛋白浓度较术前有所降低,且观察组上述指标明显高于对照组( P<0. 05 );两组术后8 d血清CD3、CD4、自然杀伤细胞(NK)、IgG、IgM、IgA浓度与CD4/CD8较术前降低,CD8较术前升高(P<0. 05);术后8 d观察组血清CD3、CD4、NK、CD4/CD8、IgG、IgM、IgA浓度高于对照组,CD8低于对照组(P<0. 05);两组术后8 d 白介素(IL)-2浓度较术前降低,且观察组高于对照组(P<0. 05);两组术后8 d IL-6浓度较术前升高,且观察组低于对照组(P<0. 05). 结论 肠内营养基础上给予四君子汤联合精氨酸可以进一步改善胃癌患者术后的营养状态与免疫功能,促进患者康复.
目的 探討四君子湯聯閤精氨痠對胃癌術後營養狀態及免疫功能的影響. 方法 2010年4月—2014年10月收治的晚期胃癌100例,隨機分為觀察組和對照組,每組50例,兩組均術後早期給予腸內營養支持,觀察組在此基礎上加用四君子湯與精氨痠,觀察兩組術後營養指標及免疫功能情況. 結果 兩組患者術後8d血紅蛋白、總膽固醇、甘油三酯、低密度脂蛋白濃度較術前有所降低,且觀察組上述指標明顯高于對照組( P<0. 05 );兩組術後8 d血清CD3、CD4、自然殺傷細胞(NK)、IgG、IgM、IgA濃度與CD4/CD8較術前降低,CD8較術前升高(P<0. 05);術後8 d觀察組血清CD3、CD4、NK、CD4/CD8、IgG、IgM、IgA濃度高于對照組,CD8低于對照組(P<0. 05);兩組術後8 d 白介素(IL)-2濃度較術前降低,且觀察組高于對照組(P<0. 05);兩組術後8 d IL-6濃度較術前升高,且觀察組低于對照組(P<0. 05). 結論 腸內營養基礎上給予四君子湯聯閤精氨痠可以進一步改善胃癌患者術後的營養狀態與免疫功能,促進患者康複.
목적 탐토사군자탕연합정안산대위암술후영양상태급면역공능적영향. 방법 2010년4월—2014년10월수치적만기위암100례,수궤분위관찰조화대조조,매조50례,량조균술후조기급여장내영양지지,관찰조재차기출상가용사군자탕여정안산,관찰량조술후영양지표급면역공능정황. 결과 량조환자술후8d혈홍단백、총담고순、감유삼지、저밀도지단백농도교술전유소강저,차관찰조상술지표명현고우대조조( P<0. 05 );량조술후8 d혈청CD3、CD4、자연살상세포(NK)、IgG、IgM、IgA농도여CD4/CD8교술전강저,CD8교술전승고(P<0. 05);술후8 d관찰조혈청CD3、CD4、NK、CD4/CD8、IgG、IgM、IgA농도고우대조조,CD8저우대조조(P<0. 05);량조술후8 d 백개소(IL)-2농도교술전강저,차관찰조고우대조조(P<0. 05);량조술후8 d IL-6농도교술전승고,차관찰조저우대조조(P<0. 05). 결론 장내영양기출상급여사군자탕연합정안산가이진일보개선위암환자술후적영양상태여면역공능,촉진환자강복.
Objective To study the effect of Sijunzi decoction combined with Arginine ( Arg) on postoperative nutritional status and immune function of patients with advanced gastric carcinoma. Methods A total of 100 patients with advanced gastric carcinoma from April 2010 to October 2014 were randomly divided into observation group (n=50) and control group (n=50). All the patients received early enteral nutritional support, and then the observation group was added with Sijunzi decoction and Arg. The postoperative nutritional indicators and immune function were observed in the two groups. Results In the two groups, the levels of hemoglobin ( Hb) , total cholesterol ( TC) , triglyceride ( TG) , low density lipoprotein ( LDL) concentration on the postoperative 8 th d were significantly lower than those before the oper-ation, and the levels in the observation group were significantly higher than those in the control group (P<0. 05);on the postoperative 8th d, the concentrations of serum CD3, CD4, natural killer cell (NK), immunoglobulin G (IgG), IgM, IgA and CD4/CD8 value were lower, while the values of CD8 concentration were higher than those before the operation (P<0. 05). On the postoperative 8th d, the concentrations of serum CD3, CD4, NK, IgG, IgM, IgA and CD4/CD8 val-ue were higher, while values of the CD8 concentration were lower in the observation group than those in the control group (P<0. 05);the concentration of IL-2 was lower than preoperative levels(P<0. 05), the concentration values of inter-leukin-2 (IL-2) were lower than those before the operation in the two groups, and the value in the observation group was significantly higher than that in the control group (P<0. 05);the concentration values of IL-6 were higher than those be-fore the operation in the two groups, and the value in the observation group was significantly lower than that in the control group (P<0. 05). Conclusion The Sijunzi decoction combined with Arg based on enteral nutrition can further improve the nutritional status and immune function of postoperative patients with advanced gastric carcinoma, and can promote re-habilitation.
