解放军医药杂志
解放軍醫藥雜誌
해방군의약잡지
Medical & Pharmaceutical Journal of Chinese People's Liberation Army
2015年
10期
88-90
,共3页
莫西沙星%肺炎%社区获得性感染%免疫功能%费用效益分析
莫西沙星%肺炎%社區穫得性感染%免疫功能%費用效益分析
막서사성%폐염%사구획득성감염%면역공능%비용효익분석
Moxifloxacin%Pneumonia%Community-acquired infections%Immune function%Cost-benefit analysis
目的 探讨莫西沙星静脉滴注联合口服序贯治疗老年社区获得性肺炎( CAP)的临床疗效及免疫功能改善情况. 方法 选择2014年5月—2015年5月收治的老年CAP 70例,随机分为观察组和对照组,每组35例. 对照组给予莫西沙星静脉滴注,观察组给予莫西沙星静脉滴注联合口服序贯治疗. 观察两组临床疗效、T细胞亚群变化及不良反应发生情况,比较两组治疗方案的成本-效果比. 结果 两组临床疗效、临床症状和体征消失时间比较差异无统计学意义(P>0. 05). 观察组治疗后CD3+、CD4+及CD4+/CD8+水平均较治疗前和对照组升高,CD8+水平均较治疗前和对照组降低(P<0. 05). 观察组不良反应发生率和成本-效果比均低于对照组(P<0. 05). 结论 莫西沙星静脉滴注联合口服序贯治疗CAP可明显改善免疫功能,不良反应发生率低,可减少住院费用.
目的 探討莫西沙星靜脈滴註聯閤口服序貫治療老年社區穫得性肺炎( CAP)的臨床療效及免疫功能改善情況. 方法 選擇2014年5月—2015年5月收治的老年CAP 70例,隨機分為觀察組和對照組,每組35例. 對照組給予莫西沙星靜脈滴註,觀察組給予莫西沙星靜脈滴註聯閤口服序貫治療. 觀察兩組臨床療效、T細胞亞群變化及不良反應髮生情況,比較兩組治療方案的成本-效果比. 結果 兩組臨床療效、臨床癥狀和體徵消失時間比較差異無統計學意義(P>0. 05). 觀察組治療後CD3+、CD4+及CD4+/CD8+水平均較治療前和對照組升高,CD8+水平均較治療前和對照組降低(P<0. 05). 觀察組不良反應髮生率和成本-效果比均低于對照組(P<0. 05). 結論 莫西沙星靜脈滴註聯閤口服序貫治療CAP可明顯改善免疫功能,不良反應髮生率低,可減少住院費用.
목적 탐토막서사성정맥적주연합구복서관치료노년사구획득성폐염( CAP)적림상료효급면역공능개선정황. 방법 선택2014년5월—2015년5월수치적노년CAP 70례,수궤분위관찰조화대조조,매조35례. 대조조급여막서사성정맥적주,관찰조급여막서사성정맥적주연합구복서관치료. 관찰량조림상료효、T세포아군변화급불량반응발생정황,비교량조치료방안적성본-효과비. 결과 량조림상료효、림상증상화체정소실시간비교차이무통계학의의(P>0. 05). 관찰조치료후CD3+、CD4+급CD4+/CD8+수평균교치료전화대조조승고,CD8+수평균교치료전화대조조강저(P<0. 05). 관찰조불량반응발생솔화성본-효과비균저우대조조(P<0. 05). 결론 막서사성정맥적주연합구복서관치료CAP가명현개선면역공능,불량반응발생솔저,가감소주원비용.
Objective To investigate clinical effect of Moxifloxacin intravenous infusion combined with oral in sequential therapy of elderly patients with community-acquired pneumonia ( CAP ) and improvement of immunological function. Methods A total of 70 elderly patients with CAP from May 2014 to May 2015 were randomly divided into ob-servation group (n=35) and control group (n=35). The control group was treated with Moxifloxacin intravenous infu-sion, while the observation group was treated with sequential therapy by Moxifloxacin intravenous infusion combined with oral medication. Clinical effect, changes of T cell subsets and incidence rate of adverse reaction in the two groups were observed, and the ratio of cost and effect in the two groups were compared. Results There were no significant differ-ences between the two groups in clinical effect, the disappearing times of clinical sings and symptoms (P>0. 05). The CD3+, CD4+ and CD4+/CD8+ levels in the observation group after the treatment were significantly higher, while the CD8+ level in the observation group after the treatment was significantly lower than those before the treatment in the ob-servation group and after the treatment in the control group ( P<0. 05 ) . The incidence rate of adverse reaction and the cost-effectiveness ratio in the observation group were significantly lower than those in the control group (P<0. 05). Con-clusion Moxifloxacin intravenous infusion combined with oral medication in Sequential therapy of elderly patients with CAP may effectively improve immune function with a low rate of adverse reaction and less cost of hospitalization.
