解放军医药杂志
解放軍醫藥雜誌
해방군의약잡지
Medical & Pharmaceutical Journal of Chinese People's Liberation Army
2015年
10期
69-71,75
,共4页
丁军颖%桂红%洪燕英%安世栋%丁雪菲%卢幼然%刘清泉
丁軍穎%桂紅%洪燕英%安世棟%丁雪菲%盧幼然%劉清泉
정군영%계홍%홍연영%안세동%정설비%로유연%류청천
耐药基因%临床感染%铜绿假单胞菌%细菌外膜蛋白
耐藥基因%臨床感染%銅綠假單胞菌%細菌外膜蛋白
내약기인%림상감염%동록가단포균%세균외막단백
Drug resistance gene%Clinical infection%Pseudomonas aeruginosa%Bacterial outer membrane pro-tein
目的 探讨2014年首都医科大学附属北京中医医院铜绿假单胞菌临床感染的分布情况,并分析其耐药特点. 方法 分离2014年全院感染病例的送检标本15 620例,留存铜绿假单胞菌,以最小抑菌浓度( MIC)法检测其对20种抗生素的敏感性,并对全耐药的铜绿假单胞菌进行耐药基因外膜蛋白D2 ( OPRD2 )的检测. 结果 本研究分离非重复病原菌5075株,铜绿假单胞菌332株(6. 54%). 标本来源以痰液为主,主要发生在疮疡外科、呼吸科和重症监护病房. 分离的铜绿假单胞菌对阿米卡星最敏感;对头孢唑啉耐药率最高. 对20种抗生素均耐药9株铜绿假单胞菌其OPRD2耐药基因并非全部缺失. 结论 临床感染铜绿假单胞菌比例大,范围广. 加强对铜绿假单胞菌感染及耐药性的监测,尤其相关耐药基因的检测,可为临床合理治疗提供依据.
目的 探討2014年首都醫科大學附屬北京中醫醫院銅綠假單胞菌臨床感染的分佈情況,併分析其耐藥特點. 方法 分離2014年全院感染病例的送檢標本15 620例,留存銅綠假單胞菌,以最小抑菌濃度( MIC)法檢測其對20種抗生素的敏感性,併對全耐藥的銅綠假單胞菌進行耐藥基因外膜蛋白D2 ( OPRD2 )的檢測. 結果 本研究分離非重複病原菌5075株,銅綠假單胞菌332株(6. 54%). 標本來源以痰液為主,主要髮生在瘡瘍外科、呼吸科和重癥鑑護病房. 分離的銅綠假單胞菌對阿米卡星最敏感;對頭孢唑啉耐藥率最高. 對20種抗生素均耐藥9株銅綠假單胞菌其OPRD2耐藥基因併非全部缺失. 結論 臨床感染銅綠假單胞菌比例大,範圍廣. 加彊對銅綠假單胞菌感染及耐藥性的鑑測,尤其相關耐藥基因的檢測,可為臨床閤理治療提供依據.
목적 탐토2014년수도의과대학부속북경중의의원동록가단포균림상감염적분포정황,병분석기내약특점. 방법 분리2014년전원감염병례적송검표본15 620례,류존동록가단포균,이최소억균농도( MIC)법검측기대20충항생소적민감성,병대전내약적동록가단포균진행내약기인외막단백D2 ( OPRD2 )적검측. 결과 본연구분리비중복병원균5075주,동록가단포균332주(6. 54%). 표본래원이담액위주,주요발생재창양외과、호흡과화중증감호병방. 분리적동록가단포균대아미잡성최민감;대두포서람내약솔최고. 대20충항생소균내약9주동록가단포균기OPRD2내약기인병비전부결실. 결론 림상감염동록가단포균비례대,범위엄. 가강대동록가단포균감염급내약성적감측,우기상관내약기인적검측,가위림상합리치료제공의거.
Objective To investigate the clinical infection distribution of Pseudomonas Aeruginosa ( P. Aerugi-nosa) in Beijing Hospital of TCM in 2014, and to analyze the characteristics of its drug resistance. Methods A total of 15 620 samples of infection cases in 2014 were isolated, and the P. Aeruginosa was reserved. The drug sensitivities a-gainst 20 antibiotics were detected using minimal inhibitory concentration ( MIC) method, and the detection for drug re-sistance gene outer membrane protein D2 (OPRD2) was performed in whole drug resistant P. Aeruginosa strains. Results A total of 5075 pathogens were isolated in this study, including the 332 P. Aeruginosa strains (6. 54%). The samples mostly came from phlegm, and the infection mostly occurred in the sores ulceration, respiratory diseases and ICU depart-ments. The isolated P. Aeruginosa had the most sensitivity against Amikacin, and the highest drug resistance rate against Cephazolin. The 9 P. Aeruginosa strains were total drug resistant against 20 antibiotics, and their OPRD2 drug resistance genes were not all lost. Conclusion The rate of P. Aeruginosa infection is high with wide range in clinical practice. To strengthen the monitoring of the P. Aeruginosa infection and drug resistance, especially to strengthen the surveillance of related genes of drug resistance may provide the basis for the reasonable treatment.
