解放军医药杂志
解放軍醫藥雜誌
해방군의약잡지
Medical & Pharmaceutical Journal of Chinese People's Liberation Army
2015年
10期
59-63
,共5页
颅内出血,高血压性%微创颅内血肿清除术%血清P物质%炎性因子
顱內齣血,高血壓性%微創顱內血腫清除術%血清P物質%炎性因子
로내출혈,고혈압성%미창로내혈종청제술%혈청P물질%염성인자
Intracranial hemorrhage%hypertensive%Minimally invasive evacuation of intracranial hematoma%Serum p substance%Inflammatory factors
目的 研究微创颅内血肿清除术对高血压脑出血患者的疗效及炎性因子、血清铁蛋白( SF)、血清P物质( SP)的影响. 方法 选择2013年5月—2015年3月江苏省人民医院收治的78例高血压脑出血患者随机分为观察组和对照组,每组39例. 对照组行常规治疗,观察组在常规治疗的基础行微创颅内血肿清除术. 比较两组治疗前和治疗后2周神经功能缺损评分、出血量、血肿周围水肿量、炎性因子水平、SF、SP变化及临床疗效. 结果 治疗后2周,两组神经功能缺损评分、出血量及血肿周围水肿量、肿瘤坏死因子-ɑ( TNF-ɑ)、白介素-6 ( IL-6 )及高敏C反应蛋白(hs-CRP)水平均显著低于治疗前,观察组上述指标显著低于对照组(P<0. 01). 两组SP水平显著高于治疗前、SF水平显著低于治疗前,观察组SP水平显著高于对照组、SF水平显著低于对照组( P<0. 01 ). 观察组总有效率高于对照组(P<0. 05). 结论 对高血压脑出血患者行微创颅内血肿清除术,有利于促进神经功能恢复,减少出血量及血肿周围水肿量,明显改善炎性因子及SP、SF水平,疗效良好.
目的 研究微創顱內血腫清除術對高血壓腦齣血患者的療效及炎性因子、血清鐵蛋白( SF)、血清P物質( SP)的影響. 方法 選擇2013年5月—2015年3月江囌省人民醫院收治的78例高血壓腦齣血患者隨機分為觀察組和對照組,每組39例. 對照組行常規治療,觀察組在常規治療的基礎行微創顱內血腫清除術. 比較兩組治療前和治療後2週神經功能缺損評分、齣血量、血腫週圍水腫量、炎性因子水平、SF、SP變化及臨床療效. 結果 治療後2週,兩組神經功能缺損評分、齣血量及血腫週圍水腫量、腫瘤壞死因子-ɑ( TNF-ɑ)、白介素-6 ( IL-6 )及高敏C反應蛋白(hs-CRP)水平均顯著低于治療前,觀察組上述指標顯著低于對照組(P<0. 01). 兩組SP水平顯著高于治療前、SF水平顯著低于治療前,觀察組SP水平顯著高于對照組、SF水平顯著低于對照組( P<0. 01 ). 觀察組總有效率高于對照組(P<0. 05). 結論 對高血壓腦齣血患者行微創顱內血腫清除術,有利于促進神經功能恢複,減少齣血量及血腫週圍水腫量,明顯改善炎性因子及SP、SF水平,療效良好.
목적 연구미창로내혈종청제술대고혈압뇌출혈환자적료효급염성인자、혈청철단백( SF)、혈청P물질( SP)적영향. 방법 선택2013년5월—2015년3월강소성인민의원수치적78례고혈압뇌출혈환자수궤분위관찰조화대조조,매조39례. 대조조행상규치료,관찰조재상규치료적기출행미창로내혈종청제술. 비교량조치료전화치료후2주신경공능결손평분、출혈량、혈종주위수종량、염성인자수평、SF、SP변화급림상료효. 결과 치료후2주,량조신경공능결손평분、출혈량급혈종주위수종량、종류배사인자-ɑ( TNF-ɑ)、백개소-6 ( IL-6 )급고민C반응단백(hs-CRP)수평균현저저우치료전,관찰조상술지표현저저우대조조(P<0. 01). 량조SP수평현저고우치료전、SF수평현저저우치료전,관찰조SP수평현저고우대조조、SF수평현저저우대조조( P<0. 01 ). 관찰조총유효솔고우대조조(P<0. 05). 결론 대고혈압뇌출혈환자행미창로내혈종청제술,유리우촉진신경공능회복,감소출혈량급혈종주위수종량,명현개선염성인자급SP、SF수평,료효량호.
Objective To investigate the curative effect of minimally invasive evacuation of intracranial hemato-ma on curative effect and inflammatory factors, serum ferritin ( SF) and P substance ( SP) of patients with hypertensive cerebral hemorrhage. Methods A total of 78 patients with hypertensive cerebral hemorrhage from May 2013 to March 2015 were randomly divided into observation group (n=39) and the control group (n=39). The control group under-went conventional treatment, while the observation group was treated with minimally invasive evacuation of intracranial hematoma on the basis of conventional treatment. neurologic impairment score, bleeding volume, edema volume around the hematoma, inflammatory factors levels, serum SF and SP changes and the curative effect were compared in the two groups before the treatment and two weeks after the treatment. Results The neurologic impairment score, bleeding vol-ume, edema volume around the hematoma, TNF-ɑ, IL-6 and hs-CRP levels two weeks after the treatment in the two groups were significantly lower than those before the treatment, and the indexes in the observation group were significantly lower than those in the control group (P<0. 01). After the treatment in the two groups, the SP levels were significantly higher, while the SF levels were significantly lower, compared with those before the treatment, and in the observation group the SP level was higher, while the SF level was significantly lower than those in the control group (P<0. 01). The total effective rate in the observation group was higher than that in the control group (P<0. 05). Conclusion The mini-mally invasive evacuation of intracranial hematoma may promote the recovery of neurological function, reduce the volumes of bleeding and edema around the hematoma, and can significantly improve levels of inflammatory factors, SP and SF of patients with hypertensive cerebral hemorrhage.
