CAJ | 학술논문

目的：比较顺铂联合甲氨蝶呤、长春花碱、阿霉素（MVAC）与顺铂联合吉西他滨（GC）治疗晚期膀胱癌的有效性和经济性。方法回顾性分析172例膀胱癌化疗患者，分为MVAC方案组（n=86）和GC方案组（n=86），比较两组的临床疗效，并运用成本-效果分析法进行经济学评价。结果 MVAC和GC组的临床有效率分别为52.3％与59.3％，差异无统计学意义（P>0.05）。MVAC组和GC组的成本有效率比分别为348.64和247.17，差异有统计学意义（P<0.05）。治疗过程中MVAC与GC组的不良反应均以血液系统毒性、消化道反应为主，两组间的差别无统计学意义。结论在疾病治疗方面，GC方案更具成本效果，而从疾病控制的角度看， MVAC方案更具成本效果。
목적：비교순박연합갑안접령、장춘화감、아매소（MVAC）여순박연합길서타빈（GC）치료만기방광암적유효성화경제성。방법회고성분석172례방광암화료환자，분위MVAC방안조（n=86）화GC방안조（n=86），비교량조적림상료효，병운용성본-효과분석법진행경제학평개。결과 MVAC화GC조적림상유효솔분별위52.3％여59.3％，차이무통계학의의（P>0.05）。MVAC조화GC조적성본유효솔비분별위348.64화247.17，차이유통계학의의（P<0.05）。치료과정중MVAC여GC조적불량반응균이혈액계통독성、소화도반응위주，량조간적차별무통계학의의。결론재질병치료방면，GC방안경구성본효과，이종질병공제적각도간， MVAC방안경구성본효과。
Objective:Objective To compare the curative effects and economy of two therapy regimens for advanced bladder cancer, which were cisplatin plus methotrexate, VLB and adriamycin (MVAC) regimen and cisplatin plus gemcitabine (GC) regimen. Methods The data were retrospectively analyzed of 172 patients with bladder cancer chemotherapy. The patients were randomly divided into MVAC group (n=86) and GC group (n=86). After treatment, the clinical curative effects were analyzed, and their pharmacoeconomics was evaluated with the cost-effectiveness analysis method. Results The ratios of clinical curative efficacy of the MVAC and GC groups were 52.3%and 59.3%respectively, having no significant differ-ences between the two groups (P>0.05). The cost-efficient ratios of MVAC group and GC group were 348.64 and 247.17 respectively, and the differences were statistically significant between the two groups (P<0.05) in this respect. The adverse reactions mainly were hematological toxicity and digestive tract reaction in both groups, and there was no statistically sig-nificant difference between them. Conclusion As for the treatment of disease, the therapeutic schedule of GC has more cost effectiveness, but the therapeutic schedule of MVAC is better in disease control.