中华急诊医学杂志
中華急診醫學雜誌
중화급진의학잡지
Chinese Journal of Emergency Medicine
2015年
10期
1126-1130
,共5页
杨志洲%刘红梅%任艺%孙兆瑞%邵旦兵%张炜%孙宝迪%唐文杰%聂时南
楊誌洲%劉紅梅%任藝%孫兆瑞%邵旦兵%張煒%孫寶迪%唐文傑%聶時南
양지주%류홍매%임예%손조서%소단병%장위%손보적%당문걸%섭시남
急性百草枯中毒%雌激素%急性肺损伤%氧化应激%大鼠%丙二醛%超氧化物歧化酶%谷胱甘肽过氧化物酶%中毒
急性百草枯中毒%雌激素%急性肺損傷%氧化應激%大鼠%丙二醛%超氧化物歧化酶%穀胱甘肽過氧化物酶%中毒
급성백초고중독%자격소%급성폐손상%양화응격%대서%병이철%초양화물기화매%곡광감태과양화물매%중독
Acute poisoning of paraquat%Estrogen%Acute lung injury%Oxidative stress%Rat%Malondialdehyde%Superoxide dismutase%Glutathione peroxidase%Poisoning
目的 研究雌激素在急性百草枯(Paraquat,PQ)中毒致大鼠急性肺损伤中的作用.方法 将96只SD大鼠随机(随机数字法)分为空白对照组、雌激素对照组、百草枯染毒组、雌激素治疗组.测定不同时段大鼠肺组织匀浆中丙二醛含量(malondialdehyde,MDA)、超氧化物歧化酶(superoxide dismutase,SOD)和谷胱甘肽过氧化物酶(glutathione peroxidase,GSH-PX)活力,同时观察14 d时各组大鼠光镜下肺组织病理学改变.结果 雌激素治疗能减轻PQ导致的MDA含量、SOD及GSH-PX活力的下降(P＜0.05),减少PQ对肺组织的破坏和肺间质内的炎症细胞浸润.结论 雌激素可通过减少PQ导致的氧化应激减轻PQ中毒大鼠的急性肺损伤.
目的 研究雌激素在急性百草枯(Paraquat,PQ)中毒緻大鼠急性肺損傷中的作用.方法 將96隻SD大鼠隨機(隨機數字法)分為空白對照組、雌激素對照組、百草枯染毒組、雌激素治療組.測定不同時段大鼠肺組織勻漿中丙二醛含量(malondialdehyde,MDA)、超氧化物歧化酶(superoxide dismutase,SOD)和穀胱甘肽過氧化物酶(glutathione peroxidase,GSH-PX)活力,同時觀察14 d時各組大鼠光鏡下肺組織病理學改變.結果 雌激素治療能減輕PQ導緻的MDA含量、SOD及GSH-PX活力的下降(P＜0.05),減少PQ對肺組織的破壞和肺間質內的炎癥細胞浸潤.結論 雌激素可通過減少PQ導緻的氧化應激減輕PQ中毒大鼠的急性肺損傷.
목적 연구자격소재급성백초고(Paraquat,PQ)중독치대서급성폐손상중적작용.방법 장96지SD대서수궤(수궤수자법)분위공백대조조、자격소대조조、백초고염독조、자격소치료조.측정불동시단대서폐조직균장중병이철함량(malondialdehyde,MDA)、초양화물기화매(superoxide dismutase,SOD)화곡광감태과양화물매(glutathione peroxidase,GSH-PX)활력,동시관찰14 d시각조대서광경하폐조직병이학개변.결과 자격소치료능감경PQ도치적MDA함량、SOD급GSH-PX활력적하강(P＜0.05),감소PQ대폐조직적파배화폐간질내적염증세포침윤.결론 자격소가통과감소PQ도치적양화응격감경PQ중독대서적급성폐손상.
Objective To study the effect of estrogen on acute lung injury patients with paraquat (PQ) poisoning.Methods Ninety-six SD rats were randomly (random number) divided into four groups,namely control group,estrogen control group,poisoning of Paraquat (PQ) and PQ treated with estrogen group.The levels of malondialdehyde (MDA),superoxide dismutase (SOD) and glutathione peroxidase in rat lungs tissue were determined at different intervals.The histopathological changes of lung tissue of rats were observed under optic microscope in each group at 14 day.Results The estrogen decreased the concentration of MDA and activity of SOD and glutathione peroxidase in case of acute poisoning of Paraquat (P ＜ 0.05).At same time,treatment with estrogen could alleviate the lung injury and inflammatory cell infiltration in the interstitium of lung.Conclusions The estrogen can reduce the degree of oxidative stress in case of acute poisoning of Paraquat,alleviating the lung injury.
