临床内科杂志
臨床內科雜誌
림상내과잡지
Journal of Clinical Internal Medicine
2015年
9期
617-620
,共4页
赵卫云%张慧敏%刘静%陈丹%程志琴%张静%高颖
趙衛雲%張慧敏%劉靜%陳丹%程誌琴%張靜%高穎
조위운%장혜민%류정%진단%정지금%장정%고영
胆囊结石%危险因素%临床预防
膽囊結石%危險因素%臨床預防
담낭결석%위험인소%림상예방
Gallstones%Risk factors%Clinical prevention
目的:探讨胆囊结石发生的相关危险因素,为预防胆囊结石提供理论依据。方法选择我院体检中心符合入选标准的2318例体检者,根据腹部超声有无胆囊结石分为胆囊结石组(485例)和非胆囊结石组(1833例),对收集的相关临床及生化指标进行统计分析。结果胆囊结石相关因素的单因素分析结果显示,年龄、性别、血清空腹血糖(FPG)、体重指数(BMI)、收缩压(SBP)、舒张压(DBP)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)及有无脂肪肝在胆囊结石组与非胆囊结石组间差异有统计学意义(P <0.01),并且随着年龄的增加,胆囊结石的检出率也增加(χ2=334.628,P <0.01);三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)及有无高尿酸血症在两组间分布差异无统计学意义(P >0.05);经多因素 Logistic 回归分析结果显示,年龄的增加、低HDL-C、高 FPG、高 SBP、超重/肥胖、患有脂肪肝为胆囊结石形成的独立危险因素(P <0.05)。性别、DBP、TC 等因素未纳入 Logistic 回归分析模式(P <0.05)。结论积极控制血压、血糖,保持脂代谢平衡,预防肥胖,进行适量的体力劳动和锻炼,并加强对脂肪肝的控制,能有效防治胆囊结石的发生,同时对具有上述风险因素的高龄人群更应加强对胆囊结石的临床防治。
目的:探討膽囊結石髮生的相關危險因素,為預防膽囊結石提供理論依據。方法選擇我院體檢中心符閤入選標準的2318例體檢者,根據腹部超聲有無膽囊結石分為膽囊結石組(485例)和非膽囊結石組(1833例),對收集的相關臨床及生化指標進行統計分析。結果膽囊結石相關因素的單因素分析結果顯示,年齡、性彆、血清空腹血糖(FPG)、體重指數(BMI)、收縮壓(SBP)、舒張壓(DBP)、總膽固醇(TC)、高密度脂蛋白膽固醇(HDL-C)及有無脂肪肝在膽囊結石組與非膽囊結石組間差異有統計學意義(P <0.01),併且隨著年齡的增加,膽囊結石的檢齣率也增加(χ2=334.628,P <0.01);三酰甘油(TG)、低密度脂蛋白膽固醇(LDL-C)及有無高尿痠血癥在兩組間分佈差異無統計學意義(P >0.05);經多因素 Logistic 迴歸分析結果顯示,年齡的增加、低HDL-C、高 FPG、高 SBP、超重/肥胖、患有脂肪肝為膽囊結石形成的獨立危險因素(P <0.05)。性彆、DBP、TC 等因素未納入 Logistic 迴歸分析模式(P <0.05)。結論積極控製血壓、血糖,保持脂代謝平衡,預防肥胖,進行適量的體力勞動和鍛煉,併加彊對脂肪肝的控製,能有效防治膽囊結石的髮生,同時對具有上述風險因素的高齡人群更應加彊對膽囊結石的臨床防治。
목적:탐토담낭결석발생적상관위험인소,위예방담낭결석제공이론의거。방법선택아원체검중심부합입선표준적2318례체검자,근거복부초성유무담낭결석분위담낭결석조(485례)화비담낭결석조(1833례),대수집적상관림상급생화지표진행통계분석。결과담낭결석상관인소적단인소분석결과현시,년령、성별、혈청공복혈당(FPG)、체중지수(BMI)、수축압(SBP)、서장압(DBP)、총담고순(TC)、고밀도지단백담고순(HDL-C)급유무지방간재담낭결석조여비담낭결석조간차이유통계학의의(P <0.01),병차수착년령적증가,담낭결석적검출솔야증가(χ2=334.628,P <0.01);삼선감유(TG)、저밀도지단백담고순(LDL-C)급유무고뇨산혈증재량조간분포차이무통계학의의(P >0.05);경다인소 Logistic 회귀분석결과현시,년령적증가、저HDL-C、고 FPG、고 SBP、초중/비반、환유지방간위담낭결석형성적독립위험인소(P <0.05)。성별、DBP、TC 등인소미납입 Logistic 회귀분석모식(P <0.05)。결론적겁공제혈압、혈당,보지지대사평형,예방비반,진행괄량적체력노동화단련,병가강대지방간적공제,능유효방치담낭결석적발생,동시대구유상술풍험인소적고령인군경응가강대담낭결석적림상방치。
Objective To investigate the risk factors of gallstones and provide theoretical basis for the prevention of gallstone.Methods A total of 2 318 people received physical examination who met the enrollment criteria in the health examination center of the first affiliated hospital of xinjiang medical university in 2013.According to the results of abdominal ultrasound,they were divided into gallstone group (485 cases)and non-gallstone group (1 833 cases).The clinical data and biochemical indices were collected and statistical analysis was carried out on the above information.Results Univariate analysis of gallstones showed that the distribution of age,gender,FPG,BMI,SBP,DBP,TC,HDL-C and fatty liver in gallstone group were significantly different with that in non-gallstone group (P <0.01 ),and with the increasing age,the detection rate of gallstones increased(trend chi-square =334.628,P <0.01).It was not different with the distribution of TG,LDL-C and UA between two groups(P >0.05).Logistic regression indicated that the increasing age,lower level of HDL-C,higher levels of FPG and SBP,overweight/obesity and fatty liver were the independent risk factors of gallstones(P <0.05),and gender,DBP,TC were not into the model of Logistic regression analysis(P <0.05).Conclusion These are effective for prevention and treatment of gallstones to control the levels of blood pressure and blood sugar,keep the balance of lipid metabolism,prevent the occurrence of obesity,make some moderate exercise and strengthen the management of the fatty liver,meanwhile,the elderly people with aboved risk factors should be focus on the clinical prevetion and treatment of gallstones.