CAJ | 학술논문

目的:探讨胸片呈不同表现的肺炎支原体肺炎(mycoplasma pneumonia,MPP)患儿的T细胞亚群变化.方法:选择MPP患儿156例,根据胸片是否呈大叶性肺炎改变分为2组,其中A组患儿胸片呈大叶性改变;B组患儿胸片呈支气管肺炎或云絮状改变.选择同期体检正常的健康儿童62名作为健康对照组(C组).检测3组患儿的T细胞亚群并比较分析.结果:A组和B组患儿的CD4 +和CD4 + / CD8 +均较C组明显降低,而CD8 +则显著升高,其中A组更为显著(P<0.01).结论:免疫损伤在MPP的起病机制中有重要作用,年龄较大的MPP患儿,胸片表现易呈大叶性肺炎,且受到的免疫抑制强.
목적:탐토흉편정불동표현적폐염지원체폐염(mycoplasma pneumonia,MPP)환인적T세포아군변화.방법:선택MPP환인156례,근거흉편시부정대협성폐염개변분위2조,기중A조환인흉편정대협성개변;B조환인흉편정지기관폐염혹운서상개변.선택동기체검정상적건강인동62명작위건강대조조(C조).검측3조환인적T세포아군병비교분석.결과:A조화B조환인적CD4 +화CD4 + / CD8 +균교C조명현강저,이CD8 +칙현저승고,기중A조경위현저(P<0.01).결론:면역손상재MPP적기병궤제중유중요작용,년령교대적MPP환인,흉편표현역정대협성폐염,차수도적면역억제강.
Objective:To explore the changes of T cell subsets in Mycoplasma pneumonia( MPP) children with different chest X-ray manifestations. Methods:One hundred and fifty-six children with MPP were divided into group A and group B according to the lobar pneumonia change. The chest X-ray in group A and group B showed the lobar pneumonia change and non-lobar pneumonia change, respectively. Sixty-two healthy children were set as the control group(group C). The T cell subsets in 3 groups were detected and analyzed. Results:Compared with group C,the levels of CD4 + and CD4 + /CD8 + in group A were significantly lower,while the level of CD8 + in group A was significantly higher(P<0. 01). Conclusions:Immune injury plays an important role in the pathogenesis of MPP. The chest X-ray in older MPP children shows lobar pneumonia,which is strongly immunodepressed.