CAJ | 학술논문

目的:探讨曲美他嗪治疗急性缺血性血管性痴呆(VD)的疗效.方法:将98例急性缺血性VD患者随机分为治疗组和对照组,对照组予阿司匹林肠溶片、辛伐他汀、血塞通和奥拉西坦治疗,疗程3周;治疗组在对照组治疗的基础上,加用曲美他嗪口服,20 mg,每天3次.分别于用药前和用药后第1、2、3周应用简易智能量表、临床痴呆评定量表和生活能力量表评分,并在用药前后检测血清总胆固醇(TCH)、三酰甘油(TG)和同型半胱氨酸(HCY)水平.结果:治疗组患者治疗后第1、2、3周简易智能量表评分逐渐升高、临床痴呆评定量表和生活能力量表评分逐渐下降,与治疗前比较,第2周后所有评分差异均有统计学意义(P<0.01).治疗3周后,治疗组总有效率83.7%,高于对照组的20.4%(P<0.01);同时治疗组TCH、TG和HCY水平均较治疗前明显下降(P<0.01),而对照组TG和HCY水平亦较治疗前下降(P<0.01);结论:曲美他嗪既能降低TCH、TG和HCY的水平,减少缺血性VD的发作,又能治疗急性缺血性VD,2周后疗效显著.
목적:탐토곡미타진치료급성결혈성혈관성치태(VD)적료효.방법:장98례급성결혈성VD환자수궤분위치료조화대조조,대조조여아사필림장용편、신벌타정、혈새통화오랍서탄치료,료정3주;치료조재대조조치료적기출상,가용곡미타진구복,20 mg,매천3차.분별우용약전화용약후제1、2、3주응용간역지능량표、림상치태평정량표화생활능역량표평분,병재용약전후검측혈청총담고순(TCH)、삼선감유(TG)화동형반광안산(HCY)수평.결과:치료조환자치료후제1、2、3주간역지능량표평분축점승고、림상치태평정량표화생활능역량표평분축점하강,여치료전비교,제2주후소유평분차이균유통계학의의(P<0.01).치료3주후,치료조총유효솔83.7%,고우대조조적20.4%(P<0.01);동시치료조TCH、TG화HCY수평균교치료전명현하강(P<0.01),이대조조TG화HCY수평역교치료전하강(P<0.01);결론:곡미타진기능강저TCH、TG화HCY적수평,감소결혈성VD적발작,우능치료급성결혈성VD,2주후료효현저.
Objective:To investigate the curative effects of trimetazidine in the treatment of acute ischemic vascular dementia. Methods:Ninety-eight patients with acute ischemic vascular dementia were randomly divided into the treatment group and control group. The control group were treated with aspirin enteric-coated tablets,simvastatin,xuesaitong combined with oxiracetam for 3 weeks, the treatment group were additionally treated with 20 mg of trimetazidine by oral,3 times a day,based on the control group. The scores of MMSE,CDR and ADL before treatment and after 1,2 and 3 weeks of treatment and levels of TCH,TG and HCY before and after treatment in two groups were measured. Results:In treatment group, the MMSE score, and CDR and ADL scores increased and decreased gradually after 1,2 and 3 weeks of treatment,respectively. The differences of the all scores between before treatment and after 2 weeks of treatment in treatment group were statistically significant(P<0. 01). After 3 weeks of treatment,the total effective rate in treatment group(83.7%)was higher than that in control group(20.4%)(P<0.01).Compared with before treatment,the levels of TCH,TG and HCY in treatment group and levels of TG and HCY in control group were significantly low after treatment(P<0. 01). Conclusions:Trimetazidine can reduce the levels of TCH, TG and HCY. Trimetazidine can reduce and treat the ischemic vascular dementia,the treatment effect of which is significant after 2 weeks of treatment.