中国药物警戒
中國藥物警戒
중국약물경계
Chinese Journal of Pharmacovigilance
2015年
10期
614-617
,共4页
金银花%山银花%电感耦合等离子体质谱%微波消解%元素分析
金銀花%山銀花%電感耦閤等離子體質譜%微波消解%元素分析
금은화%산은화%전감우합등리자체질보%미파소해%원소분석
Lonicera japonica%Lonicera hypoglauca%inductively coupled plasma mass spectrometer (ICP-MS)%microwaves digest%element analysis
目的：建立金银花和山银花两种药材中 Pb、Cu、As、Cd、Hg、Mn、Ni、Tl 等20种元素含量测定方法。方法样品经微波消解后，以 Ge，In 两种元素作为内标，电感耦合等离子体质谱仪进行分析。结果各元素的线性关系良好；方法检出限为0.004μg·L-1~0.071μg·L-1；精密度和准确度良好；回收率在80%～100%的范围内。结论测量方法灵敏度高，专属性好，可为两种药材鉴别以及质量控制提供参考。
目的：建立金銀花和山銀花兩種藥材中 Pb、Cu、As、Cd、Hg、Mn、Ni、Tl 等20種元素含量測定方法。方法樣品經微波消解後，以 Ge，In 兩種元素作為內標，電感耦閤等離子體質譜儀進行分析。結果各元素的線性關繫良好；方法檢齣限為0.004μg·L-1~0.071μg·L-1；精密度和準確度良好；迴收率在80%～100%的範圍內。結論測量方法靈敏度高，專屬性好，可為兩種藥材鑒彆以及質量控製提供參攷。
목적：건립금은화화산은화량충약재중 Pb、Cu、As、Cd、Hg、Mn、Ni、Tl 등20충원소함량측정방법。방법양품경미파소해후，이 Ge，In 량충원소작위내표，전감우합등리자체질보의진행분석。결과각원소적선성관계량호；방법검출한위0.004μg·L-1~0.071μg·L-1；정밀도화준학도량호；회수솔재80%～100%적범위내。결론측량방법령민도고，전속성호，가위량충약재감별이급질량공제제공삼고。
Objective To develop a method for the determination of a total of 20 elements such as plumbum (Pb), copper (Cu), arsenic (As), cadmium (Cd), mercury (Hg), manganese (Mn), nickel (Ni), thalliu (Tl) in Lonicera japonica and Lonicera hypoglauca. Methods The samples were digested by microwave-assisted method and then chose appropriate determination parameters of ICP-MS, using Ge and In as the internal standard. Results All the correlation coefficients exceeded 0.9993, showing good linearities over the concentration range. The lower limit of detection of the assay ranged from 0.004 to 0.071 μg·L-1. The method exhibited good precision and accuracy, while the recoveries ranged from 80% to 100%. Conclusion The method is simple, accurate and highly sensitive, successfully applied to rapid monitoring the multi-elements in Lonicera japonica and Lonicera hypoglauca for the quality control and identification.
