CAJ | 학술논문

目的探讨小剂量盐酸戊乙奎醚对脑缺血再灌注损伤大鼠血清S100B及NSE含量的影响. 方法健康Wister大鼠分成2组:缺血再灌注组( h组)、用药组( p组) ,应用ELISA法检测各组大鼠血清中S100 B蛋白和NSE蛋白的含量. 结果与缺血前比较,两组缺血后和再灌注30min后的NSE和S100B均升高,差异有统计学意义( P<0.05);与h组比较,p组患者应用长托宁后,再灌注30min时NSE和S100B均降低,差异有统计学意义( P<0.05). 结论小剂量盐酸戊乙奎醚能够降低脑缺血再灌注损伤时S100B和NSE的过量表达,起到保护作用.
목적 탐토소제량염산무을규미대뇌결혈재관주손상대서혈청S100B급NSE함량적영향. 방법 건강Wister대서분성2조:결혈재관주조( h조)、용약조( p조) ,응용ELISA법검측각조대서혈청중S100 B단백화NSE단백적함량. 결과 여결혈전비교,량조결혈후화재관주30min후적NSE화S100B균승고,차이유통계학의의( P<0.05);여h조비교,p조환자응용장탁저후,재관주30min시NSE화S100B균강저,차이유통계학의의( P<0.05). 결론 소제량염산무을규미능구강저뇌결혈재관주손상시S100B화NSE적과량표체,기도보호작용.
Objective To study effects of small doses of hydrochloric penehyclidine on cerebral ischemia reperfusion serum lev-els of S100B and NSE in rats.Methods Health Wister rats were divided into two groups:ischemia-reperfusion group(h group) and treatment group(p group).Serum S100B protein and NSE protein content in each group were detected by ELISA .Results Compared with the previous ischemia,NSE and S100B of ischemia and reperfusion after 30min were elevated in each group.The difference was statistically significant (P<0.05).Compared with h group,p group of rats with hydrochloric penehyclidine ,NSE and S100B of reperfusion after 30min were lower,the difference was statistically significant (P<0.05).Conclusion Small doses of hydrochloric penehyclidine can play a protective role by re-ducing S100B and NSE overexpression of cerebral ischemia reperfusion injury .