潍坊医学院学报
濰坊醫學院學報
유방의학원학보
Acta Academiae Medicinae Weifang
2015年
5期
374-377
,共4页
刘建美%项锋钢%连文静%周立%吴宏
劉建美%項鋒鋼%連文靜%週立%吳宏
류건미%항봉강%련문정%주립%오굉
妊娠期高血压%Kif2a%β-catenin%MMP-1
妊娠期高血壓%Kif2a%β-catenin%MMP-1
임신기고혈압%Kif2a%β-catenin%MMP-1
PIH%Kif2a%β-catenin%MMP-1
目的 检测Kif2a,β-catenin,MMP-1在妊娠高血压患者胎盘组织中的表达,并探讨其与妊娠期高血压的关系. 方法 选取妊娠期高血压患者28例、子痫前期27例、正常妊娠27例胎盘组织标本,采用免疫组化检测Kif2a,β-catenin,MMP-1的表达情况. 结果 免疫组化显示妊娠期高血压和子痫前期患者胎盘组织中Kif2a,β-cateni,MMP-1的表达明显低于正常妊娠组( P<0.05),且3个指标在子痫前期组胎盘组织中表达低于妊娠高血压病组,差异有统计学意义(P<0.05). 在妊娠期高血压组中, Kif2a与β-catenin的表达之间呈显著正相关(r=-0.392,P=0.005);β-catenin与MMP-1的表达之间呈显著正相关(r=-0.349,P=0.008);Kif2a与MMP-1的表达之间呈显著正相关(r=-0.367,P=0.004). 结论 妊娠期高血压病人胎盘Kif2a,β-catenin, MMP-1表达均明显减少,推测三者可能协同参与了妊娠期高血压的发病过程.
目的 檢測Kif2a,β-catenin,MMP-1在妊娠高血壓患者胎盤組織中的錶達,併探討其與妊娠期高血壓的關繫. 方法 選取妊娠期高血壓患者28例、子癇前期27例、正常妊娠27例胎盤組織標本,採用免疫組化檢測Kif2a,β-catenin,MMP-1的錶達情況. 結果 免疫組化顯示妊娠期高血壓和子癇前期患者胎盤組織中Kif2a,β-cateni,MMP-1的錶達明顯低于正常妊娠組( P<0.05),且3箇指標在子癇前期組胎盤組織中錶達低于妊娠高血壓病組,差異有統計學意義(P<0.05). 在妊娠期高血壓組中, Kif2a與β-catenin的錶達之間呈顯著正相關(r=-0.392,P=0.005);β-catenin與MMP-1的錶達之間呈顯著正相關(r=-0.349,P=0.008);Kif2a與MMP-1的錶達之間呈顯著正相關(r=-0.367,P=0.004). 結論 妊娠期高血壓病人胎盤Kif2a,β-catenin, MMP-1錶達均明顯減少,推測三者可能協同參與瞭妊娠期高血壓的髮病過程.
목적 검측Kif2a,β-catenin,MMP-1재임신고혈압환자태반조직중적표체,병탐토기여임신기고혈압적관계. 방법 선취임신기고혈압환자28례、자간전기27례、정상임신27례태반조직표본,채용면역조화검측Kif2a,β-catenin,MMP-1적표체정황. 결과 면역조화현시임신기고혈압화자간전기환자태반조직중Kif2a,β-cateni,MMP-1적표체명현저우정상임신조( P<0.05),차3개지표재자간전기조태반조직중표체저우임신고혈압병조,차이유통계학의의(P<0.05). 재임신기고혈압조중, Kif2a여β-catenin적표체지간정현저정상관(r=-0.392,P=0.005);β-catenin여MMP-1적표체지간정현저정상관(r=-0.349,P=0.008);Kif2a여MMP-1적표체지간정현저정상관(r=-0.367,P=0.004). 결론 임신기고혈압병인태반Kif2a,β-catenin, MMP-1표체균명현감소,추측삼자가능협동삼여료임신기고혈압적발병과정.
Objective To test the expression of Kif2a,β-catenin and MMP-1in the human placenta of pregnancy induced hyper-tension syndrome(PIH) patients,and discuss its relationship with PIH.Methods The 28 cases of PIH,27 cases of pre-eclampsia and 27 placental tissue specimen of normal pregnancy were selected ,and adopt immunohistochemistry to test the expression of Kif 2a,β-catenin and MMP-1.Results The immunohistochemistry indicates that the expression of Kif 2a,β-catenin and MMP-1 in the human placenta of PIH and pre-eclampsia patients isevidently under the group of normal pregnancy (P<0.05).The three index in human placenta cases are lower than in the PIH cases.The difference was statistically significant (P<0.05).In the group of PIH,the expression of Kif2a and β-catenin has the significant positive correlation(r=-0.392,P=0.005);the expression of β-catenin and MMP-1 has the significant positive correlation (r=-0.349,P=0.008);the expression of Kif2a and MMP-1 has the significant positive correlation (r=-0.367,P=0.004).Conclusion The expression of Kif2a,β-catenin and MMP-1 in the human placenta of PIH patients are significantly reduced .Speculated that Kif2a,β-cate-nin and MMP-1 probably participate in the happening of PIH .
