CAJ | 학술논문

为研究口服槟榔(Areca catechu Linnaeus)仁汁液的毒性,进行了小鼠的经口急性毒性试验. 根据预试验确定正式试验给药剂量的范围,选用KM小鼠经口灌胃,一次给药,给药后连续观察7 d,记录小白鼠的中毒反应及死亡情况,采用寇氏法计算 LD50及LD50的95%可信限.结果表明,高剂量给药组小白鼠出现中毒反应并死亡,解剖后检查发现主要原因是胃肠和肺部的病变,测得槟榔仁汁液的LD50及LD50的95%可信限分别为12.425 g/(kg.bw)﹑10.610~14.551 g/(kg.bw), 表明槟榔仁汁液可以被认为是实际无毒物质. 槟榔仁原液干物质的LD50及LD50的95%可信限分别为1.349 g/(kg.bw)﹑1.152~1.580 g/(kg.bw),属于低毒物质.
위연구구복빈랑(Areca catechu Linnaeus)인즙액적독성,진행료소서적경구급성독성시험. 근거예시험학정정식시험급약제량적범위,선용KM소서경구관위,일차급약,급약후련속관찰7 d,기록소백서적중독반응급사망정황,채용구씨법계산 LD50급LD50적95%가신한.결과표명,고제량급약조소백서출현중독반응병사망,해부후검사발현주요원인시위장화폐부적병변,측득빈랑인즙액적LD50급LD50적95%가신한분별위12.425 g/(kg.bw)﹑10.610~14.551 g/(kg.bw), 표명빈랑인즙액가이피인위시실제무독물질. 빈랑인원액간물질적LD50급LD50적95%가신한분별위1.349 g/(kg.bw)﹑1.152~1.580 g/(kg.bw),속우저독물질.
The acute oxicity was tested in mice in order to study the oral toxicity of the juice of betel nut seeds.According to preliminary experiments to determine the range of the official test administered dose,KM mice were selected and administered drug by intragastric infusion at single dose,the toxic effect and death condition of the mice were observed for 7 days after being administered, and the method of korbor was used to determine LD50 and 95% confidence level.The results showed that the high dose of betel nut juice to mice appeared toxic reactions and death, and the main reason was gastrointestinal and lung disease after autopsy;low dose group was no pathological change in viscera in mice.The LD50 of betel nut juice in mice was 12.425 g/kg and its 95% confidence level was 10.610~14.551 g/kg,which indicated that the betel nut juice was actual non-toxic substances.The LD50 of dry matter of betel nut juice was 1.349 g/kg and its 95% confidence level was 1.152~1.580 g/kg and it was considered the drug of low toxicity.