CAJ | 학술논문

目的比较原发韦氏环非霍奇金淋巴瘤(WRNHL)常见病理类型的临床特征与预后差异.方法对2008年1月至2013年12月收治的50例原发WRNHL患者的临床资料进行回顾性分析.Kaplan-Meier法计算生存率,用Log-rank法检验组间差异并行单因素预后分析.结果原发WRNHL常见病理类型为弥漫大B细胞淋巴瘤(DLBCL)与结外鼻型NK/T细胞淋巴瘤(ENKTCL),其中DLBCL占56％(28/50),ENKTCL占34％(17/50).DLBCL的发病年龄明显大于ENKTCL,两者原发部位不同,50.0％(14/28)的DLBCL患者原发于扁桃体,88.2％(15/17)的ENKTCL原发于鼻咽部;DLBCL的近期疗效远优于ENKTCL, DLBCL的总生存率、无进展生存率均优于ENKTCL,差异均有统计学意义(x2=4.45,P=0.035;x2=6.47,P=0.011).结论 DLBCL和ENKTCL的临床特征不同,DLBCL的近期疗效及预后明显优于ENKTCL.
목적 비교원발위씨배비곽기금림파류(WRNHL)상견병리류형적림상특정여예후차이.방법 대2008년1월지2013년12월수치적50례원발WRNHL환자적림상자료진행회고성분석.Kaplan-Meier법계산생존솔,용Log-rank법검험조간차이병행단인소예후분석.결과 원발WRNHL상견병리류형위미만대B세포림파류(DLBCL)여결외비형NK/T세포림파류(ENKTCL),기중DLBCL점56％(28/50),ENKTCL점34％(17/50).DLBCL적발병년령명현대우ENKTCL,량자원발부위불동,50.0％(14/28)적DLBCL환자원발우편도체,88.2％(15/17)적ENKTCL원발우비인부;DLBCL적근기료효원우우ENKTCL, DLBCL적총생존솔、무진전생존솔균우우ENKTCL,차이균유통계학의의(x2=4.45,P=0.035;x2=6.47,P=0.011).결론 DLBCL화ENKTCL적림상특정불동,DLBCL적근기료효급예후명현우우ENKTCL.
Objective To compare the clinicopathological characteristics and prognosis of primary Waldeyer's ring non-Hodgkin lymphoma.Methods From Jan 2008 to Dcc 2013, 50 patients with primary Waldeyer's ring non-Hodgkin lymphoma were retrospectively analyzed.Kaplan-Meier method was used for survival analysis.Log-rank method was used for univariate analysis.Results Waldeyer's ring diffuse large B-cell lymphoma (DLBCL) and extranodal nasal-type NK/T-cell lymphoma (ENKTCL) were the common pathological types of primary Waldeyer's ring non-Hodgkin lymphoma accounting for 56 ％ (28/50) DLBCL and 34 ％ (17/50) ENKTCL, respectively.The age at onset of ENKTCL patients was younger than that of DLBCL patients.Two groups had different primary sites, including 50.0 ％ (14/28) of DLBCL with tonsillar disease and 88.2 ％ (15/17) of ENKTCL with nasopharynx disease.The short phase effect of DLBCL group was higher than that of ENKTCL group.The overall survival (OS) and progression-free survival (PFS) rates had significant differences between DLBCL and ENKTCL (x2 =4.45, P =0.035;x2=6.47, P =0.011).Conclusion DLBCL and ENKTCL are different in clinical characteristics.The short phase effect and prognosis of DLBCL are obviously better than those of the ENKTCL.