CAJ | 학술논문

目的：探讨替吉奥联合周疗法紫杉醇脂质体治疗晚期胃癌的疗效及毒副反应。方法26例晚期胃癌患者接受替吉奥胶囊和周疗法紫杉醇脂质体联合化疗，每6周为1周期，每周期评估疗效，包括有效率、疾病无进展生存期、总生存期，同时评估化疗的毒副反应。结果26例患者中，CR 0例，PR 9例，SD 14例，PD 3例，有效率为34.6%，疾病控制率为88.5%，中位无进展生存期为6.0个月，中位生存期为10.0个月。主要毒副反应为骨髓抑制和胃肠道反应，Ⅲ、Ⅳ度毒副反应包括中性粒细胞减少2例（7.7%），恶心呕吐1例（3.9%）和腹泻1例（3.9%）。结论替吉奥联合周疗法紫杉醇脂质体治疗进展期胃癌疗好，毒副反应轻，可推荐为晚期胃癌尤其是年老体弱患者的治疗选择。
목적：탐토체길오연합주요법자삼순지질체치료만기위암적료효급독부반응。방법26례만기위암환자접수체길오효낭화주요법자삼순지질체연합화료，매6주위1주기，매주기평고료효，포괄유효솔、질병무진전생존기、총생존기，동시평고화료적독부반응。결과26례환자중，CR 0례，PR 9례，SD 14례，PD 3례，유효솔위34.6%，질병공제솔위88.5%，중위무진전생존기위6.0개월，중위생존기위10.0개월。주요독부반응위골수억제화위장도반응，Ⅲ、Ⅳ도독부반응포괄중성립세포감소2례（7.7%），악심구토1례（3.9%）화복사1례（3.9%）。결론체길오연합주요법자삼순지질체치료진전기위암료호，독부반응경，가추천위만기위암우기시년로체약환자적치료선택。
Objective To investigate the efficacy and toxicities of S-1 combined with weekly paclitaxel liposome chemotherapy in the treatment of advanced gastric cancer. Methods Twenty-six patients with advanced gastric cancer were treated with S-1 combined with paclitaxel liposome. Six weeks administration was considered as one cycle. The ef-ficacy including the response rate,the progression-free survival and the overall survival as well as toxicities were evalua-ted every cycle. Results The response rate was 34. 6%,and the disease control rate was 88. 5%( CR in the 0 pa-tient,PR in the 9 patients,SD in the 14 patients and PD in the 3 patients). The median progression-free survival and o-verall survival time was 6. 0 and 10. 0 months,respectively. The main toxicities were hematological toxicity and gastro-intestinal reaction. GradeⅢandⅣtoxicities included 2 cases(7. 7%)of neutropenia,1 case(3. 9%)of nausea and vomiting and 1 case(3. 9%)of diarrhea. Conclusion S-1 combined with weekly paclitaxel liposome is effective and well tolerated for patients with advanced gastric cancer.