CAJ | 학술논문

目的：观察培美曲塞联合卡培他滨治疗复发转移性乳腺癌的临床疗效和毒副反应。方法29例复发转移性乳腺癌患者均接受培美曲塞联合卡培他滨治疗，3周重复，所有病例接受2周期以上的化疗，并评价疗效和毒副反应。结果29例患者的有效率为27.6%，疾病控制率为58.6%。毒副反应主要为胃肠道反应、骨髓抑制、皮疹及手足综合征，患者均可耐受。结论培美曲塞联合卡培他滨治疗复发转移性乳腺癌高效、低毒、可耐受，对蒽环类和紫杉醇类药物无效的患者仍然有效，值得临床推广研究。
목적：관찰배미곡새연합잡배타빈치료복발전이성유선암적림상료효화독부반응。방법29례복발전이성유선암환자균접수배미곡새연합잡배타빈치료，3주중복，소유병례접수2주기이상적화료，병평개료효화독부반응。결과29례환자적유효솔위27.6%，질병공제솔위58.6%。독부반응주요위위장도반응、골수억제、피진급수족종합정，환자균가내수。결론배미곡새연합잡배타빈치료복발전이성유선암고효、저독、가내수，대은배류화자삼순류약물무효적환자잉연유효，치득림상추엄연구。
Objective To investigate the clinical curative effect and toxicities of pemetrexed combined with capecitabine in the treatment of recurrent and metastatic breast cancer. Methods 29 patients with recurrent and metastatic breast cancer received the pemetrexed combined with capecitabine,three weeks were one cycle,All the patients accepted at least 2 cycles of chemotherapy,and the clinical curative effect and toxicities were observed. Re-sults In the 29 patients,the efficient rate was 27. 6%,the disease control rates was 58. 6%. The major toxicities were bone marrow suppression,gastrointestinal reaction,rash and hand-foot syndrome,and could be tolerated. Con-clusion Pemetrexed combined with capecitabine is safe and effect in the treatment of recurrent and metastatic breast cancer.