CAJ | 학술논문

目的：探讨经皮植入药盒系统肝动脉持续灌注氟尿嘧啶脱氧核苷（ FUDR）治疗晚期原发性肝癌的临床疗效和安全性。方法56例无外科手术指征的晚期原发性肝癌患者分为观察组及对照组。观察组28例采取经左锁骨下动脉植入药盒肝动脉内灌注FUDR 0.4 mg·m-2·d-1，持续14 d，每21 d重复1次；对照组进行最佳支持治疗，比较2组的甲胎蛋白（ AFP）变化、生活质量及生存时间。结果观察组AFP下降超过20%者占32.1%，KPS评分改善者占42.9%，中位生存期6.5个月，与对照组的3.6%、10.7%及3.8个月比较差异有统计学意义（ P<0.05）。观察组治疗的毒副反应可以耐受。结论经皮植入药盒系统肝动脉持续灌注FUDR可改善患者的生活质量，延长生存时间，是治疗晚期原发性肝癌的有效方法之一。
목적：탐토경피식입약합계통간동맥지속관주불뇨밀정탈양핵감（ FUDR）치료만기원발성간암적림상료효화안전성。방법56례무외과수술지정적만기원발성간암환자분위관찰조급대조조。관찰조28례채취경좌쇄골하동맥식입약합간동맥내관주FUDR 0.4 mg·m-2·d-1，지속14 d，매21 d중복1차；대조조진행최가지지치료，비교2조적갑태단백（ AFP）변화、생활질량급생존시간。결과관찰조AFP하강초과20%자점32.1%，KPS평분개선자점42.9%，중위생존기6.5개월，여대조조적3.6%、10.7%급3.8개월비교차이유통계학의의（ P<0.05）。관찰조치료적독부반응가이내수。결론경피식입약합계통간동맥지속관주FUDR가개선환자적생활질량，연장생존시간，시치료만기원발성간암적유효방법지일。
Objective To investigate the clinical efficacy and toxicities of continuous hepatic arterial infusion chemotherapy with floxuridine via port-catheter system in the treatment of advanced primary hepatocellular carcino-ma. Methods Fifty-six patients with advanced primary hepatocellular carcinoma were divided into the observation group and the control group. The 28 patients in the observation group received continuous hepatic arterial infusion chemotherapy with FUDR(0. 4 mg·m-2 ·d-1 for 14 days,a cycle of 21 days)via port-catheter system;the 28 patients in the control group received the best supportive care. The changes of alpha-fetoprotein( AFP),quality of life,survival time were observed. Results Among 28 patients in the observation group,9 patients( 32. 1%) showed more than a 20% decrease in their serum AFP levels from baseline,the KPS score improving rates was 42. 9%,and the median overall survival time was 6. 5 months;and were 3. 6%,10. 7% and 3. 8 months in the con-trol group(P <0. 05). The toxicities could be tolerated. Conclusion The continuous hepatic arterial infusion chemotherapy with FUDR via port-catheter system is safe and effective in the treatment of advanced primary hepato-cellular carcinoma.