CAJ | 학술논문

目的：探讨颞叶内侧癫（mesial temporal lobe epilepsy ，MTLE）患者血清蛋白S100B的浓度变化；分析病例组中海马硬化组与非硬化组中S100B的差别，以探讨其是否与海马硬化程度有关。方法：利用ELISA法测定30例颞叶癫?患者的血清蛋白S100B浓度，以同期在我院儿科就诊的上呼吸道感染和腹泻恢复期患者及体检中心体检的正常成人30例作为对照；根据患者MRI海马有无硬化分为两组，分析两组血清 S100B 的差别。结果：30例 MTLE 患者血清 S100B 浓度为（0．255±0．074）μg／L ，与30例正常对照组（0．108±0．020）μg／L比较差异有统计学意义（ P＝0．001）；伴有海马硬化患者血清S100B （0．303±0．052）μg／L水平显著高于无海马硬化者（0．222±0．068）μg／L （ P＝0．002）。结论：S100B可能是MTLE的生物标志物，并可能反映海马硬化程度。
목적：탐토섭협내측전（mesial temporal lobe epilepsy ，MTLE）환자혈청단백S100B적농도변화；분석병례조중해마경화조여비경화조중S100B적차별，이탐토기시부여해마경화정도유관。방법：이용ELISA법측정30례섭협전?환자적혈청단백S100B농도，이동기재아원인과취진적상호흡도감염화복사회복기환자급체검중심체검적정상성인30례작위대조；근거환자MRI해마유무경화분위량조，분석량조혈청 S100B 적차별。결과：30례 MTLE 환자혈청 S100B 농도위（0．255±0．074）μg／L ，여30례정상대조조（0．108±0．020）μg／L비교차이유통계학의의（ P＝0．001）；반유해마경화환자혈청S100B （0．303±0．052）μg／L수평현저고우무해마경화자（0．222±0．068）μg／L （ P＝0．002）。결론：S100B가능시MTLE적생물표지물，병가능반영해마경화정도。
Objective:To investigate the chanfes of the concentration of serum S100B in patients with mesial temporal lobe epilepsy ,and analyze the difference of serum S100B between MTLE‐HS pa‐tients and MTLE patients without HS ,in order to explove whether it is associated with the degree of hip‐pocampal sclerosis .Methods:The conceutration of plasma S100B levels by ELISA was measured in 30 pa‐tients with MTLE and 30 healthy controls and their diffenences were analyzed .Results:The serum S100B levels in 30 patients with MTLE had siqnificant changes compared with healthy controls (P= 0 .001) . Moreover ,S100B levels were significantly higher MTLE‐HS patients than those MTLE patients without HS (P=0 .002) .Conclusion:S100B may be a biomarker of MTLE ,and may reflect the degree of hipp‐ocampal sclerosis .