CAJ | 학술논문

目的：探讨复方苦参注射液联合GP方案治疗老年晚期非小细胞肺癌的近期疗效和毒副反应。方法90例老年晚期非小细胞肺癌患者随机均分为2组（观察组和对照组），每组45例，均接受GP方案治疗，观察组同时给予复方苦参注射液治疗。治疗期间比较观察2组的近期疗效和毒副反应。结果观察组有效率和疾病控制率分别为46.67%（21/45）和77.78%（35/45），对照组分别为42.22%（19/45）和66.67%（30/45），观察组略高，但差异无统计学意义（ P跃0.05）。观察组白细胞减少、血红蛋白减少、血小板减少、恶心呕吐、乏力发生率均低于对照组，差异有统计学意义（ P<0.05）。结论复方苦参注射液与GP方案联合用于老年晚期非小细胞肺癌的治疗，疗效较好，安全性明显提高。
목적：탐토복방고삼주사액연합GP방안치료노년만기비소세포폐암적근기료효화독부반응。방법90례노년만기비소세포폐암환자수궤균분위2조（관찰조화대조조），매조45례，균접수GP방안치료，관찰조동시급여복방고삼주사액치료。치료기간비교관찰2조적근기료효화독부반응。결과관찰조유효솔화질병공제솔분별위46.67%（21/45）화77.78%（35/45），대조조분별위42.22%（19/45）화66.67%（30/45），관찰조략고，단차이무통계학의의（ P약0.05）。관찰조백세포감소、혈홍단백감소、혈소판감소、악심구토、핍력발생솔균저우대조조，차이유통계학의의（ P<0.05）。결론복방고삼주사액여GP방안연합용우노년만기비소세포폐암적치료，료효교호，안전성명현제고。
Objective To investigate the short-term efficacy and toxicities of fufang kushen injection combined with GP regimen in the treatment of elderly patients with advanced non-small-cell lung cancer. Methods All the 90 elderly patients with advanced non-small-cell lung cancer were divided in two groups(45 patients of the observation group and 45 patients of the control group),and received the GP regimen chemotherapy,45 patients of the observa-tion group received fufang kushen injection at the same time. The short-term efficacy and toxicities were compared between the two groups. Results The response rate and the disease control rate of the observation group were 46. 67%(21/45)and 77. 78%(35/45),and were 42. 22%(19/45)and 66. 67%(30/45)of the control group (P>0. 05). The incidences of leucopenia,anemia,thrombocytopenia,nausea and vomiting anergy of the observation group were higher than those of the control group(P<0. 05). Conclusion Fufang kushen injection combined with GP regimen is effective and safe in the treatment of elderly patients with advanced non-small-cell lung cancer.