中国中西医结合影像学杂志
中國中西醫結閤影像學雜誌
중국중서의결합영상학잡지
Chinese Imaging Journal of Integrated Traditional and Western Medicine
2015年
5期
511-514
,共4页
甲状腺结节%99Tcm-HL91%乏氧显像%放射性核素显像
甲狀腺結節%99Tcm-HL91%乏氧顯像%放射性覈素顯像
갑상선결절%99Tcm-HL91%핍양현상%방사성핵소현상
Thyroid nodules%99Tcm-HL91%Hypoxia imaging%Radionuclide imaging
目的:探讨 99Tcm-HL91乏氧细胞分子显像对甲状腺冷结节的诊断价值. 方法:对30例 99TcmO4-甲状腺扫描提示为冷结节的患者术前行 99Tcm-HL91早(10 min)、中(2 h)、晚(4 h)三时相显像,对显像结果进行定性和半定量分析,并对照病理结果.30例中,经病理或细针穿刺活检证实恶性病变18例,良性病变12例.结果:根据病理检查结果,99Tcm-HL91乏氧细胞定性诊断的灵敏度、特异度及准确度分别为88.9%(16/18)、83.3%(10/12)、86.7%(26/30). 半定量分析:延迟4 h诊断的灵敏度、特异度及准确度分别为94.4%(17/18)、91.7%(11/12)、93.3%(28/30);良性组与恶性组三时相的靶本比值(T/N)、早期摄取比值(ER)、延迟2 h摄取比值(DR1)、延迟4 h摄取比值(DR2)差异均有统计学意义,良性组与恶性组的延迟2 h滞留指数(RI1)差异无统计学意义,延迟4 h滞留指数(RI2)差异有统计学意义. 结论:99Tcm-HL91乏氧细胞分子显像对甲状腺孤立冷结节良恶性的鉴别诊断有一定的临床价值;半定量分析较定性分析更能准确鉴别结节性质;延迟4h显像较2h更能提高诊断的灵敏度、特异度和准确度.
目的:探討 99Tcm-HL91乏氧細胞分子顯像對甲狀腺冷結節的診斷價值. 方法:對30例 99TcmO4-甲狀腺掃描提示為冷結節的患者術前行 99Tcm-HL91早(10 min)、中(2 h)、晚(4 h)三時相顯像,對顯像結果進行定性和半定量分析,併對照病理結果.30例中,經病理或細針穿刺活檢證實噁性病變18例,良性病變12例.結果:根據病理檢查結果,99Tcm-HL91乏氧細胞定性診斷的靈敏度、特異度及準確度分彆為88.9%(16/18)、83.3%(10/12)、86.7%(26/30). 半定量分析:延遲4 h診斷的靈敏度、特異度及準確度分彆為94.4%(17/18)、91.7%(11/12)、93.3%(28/30);良性組與噁性組三時相的靶本比值(T/N)、早期攝取比值(ER)、延遲2 h攝取比值(DR1)、延遲4 h攝取比值(DR2)差異均有統計學意義,良性組與噁性組的延遲2 h滯留指數(RI1)差異無統計學意義,延遲4 h滯留指數(RI2)差異有統計學意義. 結論:99Tcm-HL91乏氧細胞分子顯像對甲狀腺孤立冷結節良噁性的鑒彆診斷有一定的臨床價值;半定量分析較定性分析更能準確鑒彆結節性質;延遲4h顯像較2h更能提高診斷的靈敏度、特異度和準確度.
목적:탐토 99Tcm-HL91핍양세포분자현상대갑상선랭결절적진단개치. 방법:대30례 99TcmO4-갑상선소묘제시위랭결절적환자술전행 99Tcm-HL91조(10 min)、중(2 h)、만(4 h)삼시상현상,대현상결과진행정성화반정량분석,병대조병리결과.30례중,경병리혹세침천자활검증실악성병변18례,량성병변12례.결과:근거병리검사결과,99Tcm-HL91핍양세포정성진단적령민도、특이도급준학도분별위88.9%(16/18)、83.3%(10/12)、86.7%(26/30). 반정량분석:연지4 h진단적령민도、특이도급준학도분별위94.4%(17/18)、91.7%(11/12)、93.3%(28/30);량성조여악성조삼시상적파본비치(T/N)、조기섭취비치(ER)、연지2 h섭취비치(DR1)、연지4 h섭취비치(DR2)차이균유통계학의의,량성조여악성조적연지2 h체류지수(RI1)차이무통계학의의,연지4 h체류지수(RI2)차이유통계학의의. 결론:99Tcm-HL91핍양세포분자현상대갑상선고립랭결절량악성적감별진단유일정적림상개치;반정량분석교정성분석경능준학감별결절성질;연지4h현상교2h경능제고진단적령민도、특이도화준학도.
Objective:To evaluate the diagnostic value of 99Tcm-HL91 molecular imaging of hypoxic cell in diagnosis of thyroid cold nodules. To evaluate the value of molecular imaging of hypoxic cell in diagnosis of thyroid cold nodules ,through research-ing the value of 99Tcm-HL91 hypoxia imaging in diagnosis of thyroid cold nodules. Methods:30 patients,whose 99TcmO4- static imaging prompted cold nodules,underwent 99Tcm-HL91 hypoxia imaging of early,middle and late-phase before operation. And then analyzing the imaging results with qualitative and semi-quantitative method. Finally,the appropriate statistical analysis was done with all these results. Results:According to the biopsy results,about qualitative analysis:The diagnostic sensitivity,accuracy and specificity of 99Tcm-HL91 molecular imaging of hypoxic cell was 88.9%,83.3%,and 86.7%,respectively. Semi-quantitative analysis:the diagnostic sensitivity,accuracy,specificity of 4 h was 94.4%,91.7%,93.3% respectively. The differences between be-nign group and malignant group about T/N ratio of three phases,ER,DR1,DR2 were all statistically significant,the RI1 between benign and malignant group was no significant difference,but there was statistical significant about RI2. Conclusion:As a non-specific pro-tumor imaging agent,99Tcm-HL91 has some clinical value for the differential diagnosis of thyroid cold nodules. Comparing semi-quantitative analysis and qualitative analysis,the former is more accurate in detecting the nature of nodules. 4 h delayed phase can enhance the sensitivity,accuracy and specificity than 2 h delayed phase.
