福建医药杂志
福建醫藥雜誌
복건의약잡지
Fujian Medical Journal
2015年
5期
61-64
,共4页
亚临床甲状腺机能减退症%促甲状腺素%高胰岛素血症%胰岛素抵抗
亞臨床甲狀腺機能減退癥%促甲狀腺素%高胰島素血癥%胰島素牴抗
아림상갑상선궤능감퇴증%촉갑상선소%고이도소혈증%이도소저항
subclinical hypothyroidism%TSH%hyperinsulinemia%insulin resistance
目的：探讨老年亚临床甲状腺机能减退症（SCH）患者促甲状腺素（TSH）水平与胰岛素抵抗的关系。方法选取老年SCH患者65例，按TSH水平分为两组，即SCH 1组（TSH 4.12～10 mIu／L）和SCH 2组（TSH≥10 mIu／L），并设对照组（TSH＜4.12 mIu／L）42人，分析比较3组血脂、血糖、胰岛素水平，并计算稳态模式下的胰岛素分泌指数（HOMA‐β）及胰岛素抵抗指数（HOMA‐IR）。结果与对照组相比，SCH 1组及SCH 2组TC、LDL‐C均较高（均 P＜0.005）；FINS、HOMA‐β也增高（均 P＜0.05）。SCH 2组FINS水平较SCH 1组高（P＜0.05），SCH 1组HOMA‐IR与对照组比较，差异无统计学意义（P＞0.05），而SCH 2组的HOMA‐IR比对照组高（P＜0.05）。结论老年SCH患者存在血脂紊乱和高胰岛素血症及胰岛素抵抗， TSH水平越高，高胰岛素血症和胰岛素抵抗就越明显。
目的：探討老年亞臨床甲狀腺機能減退癥（SCH）患者促甲狀腺素（TSH）水平與胰島素牴抗的關繫。方法選取老年SCH患者65例，按TSH水平分為兩組，即SCH 1組（TSH 4.12～10 mIu／L）和SCH 2組（TSH≥10 mIu／L），併設對照組（TSH＜4.12 mIu／L）42人，分析比較3組血脂、血糖、胰島素水平，併計算穩態模式下的胰島素分泌指數（HOMA‐β）及胰島素牴抗指數（HOMA‐IR）。結果與對照組相比，SCH 1組及SCH 2組TC、LDL‐C均較高（均 P＜0.005）；FINS、HOMA‐β也增高（均 P＜0.05）。SCH 2組FINS水平較SCH 1組高（P＜0.05），SCH 1組HOMA‐IR與對照組比較，差異無統計學意義（P＞0.05），而SCH 2組的HOMA‐IR比對照組高（P＜0.05）。結論老年SCH患者存在血脂紊亂和高胰島素血癥及胰島素牴抗， TSH水平越高，高胰島素血癥和胰島素牴抗就越明顯。
목적：탐토노년아림상갑상선궤능감퇴증（SCH）환자촉갑상선소（TSH）수평여이도소저항적관계。방법선취노년SCH환자65례，안TSH수평분위량조，즉SCH 1조（TSH 4.12～10 mIu／L）화SCH 2조（TSH≥10 mIu／L），병설대조조（TSH＜4.12 mIu／L）42인，분석비교3조혈지、혈당、이도소수평，병계산은태모식하적이도소분비지수（HOMA‐β）급이도소저항지수（HOMA‐IR）。결과여대조조상비，SCH 1조급SCH 2조TC、LDL‐C균교고（균 P＜0.005）；FINS、HOMA‐β야증고（균 P＜0.05）。SCH 2조FINS수평교SCH 1조고（P＜0.05），SCH 1조HOMA‐IR여대조조비교，차이무통계학의의（P＞0.05），이SCH 2조적HOMA‐IR비대조조고（P＜0.05）。결론노년SCH환자존재혈지문란화고이도소혈증급이도소저항， TSH수평월고，고이도소혈증화이도소저항취월명현。
Objective To explore the association of TSH levels with insulin resistance in a senile population with subclin‐ical hypothyroidism .Methods A total of 65 elderly patients with SCH were divided into two groups by TSH levels as follows :SCH 1 group (4.12 mIu/L< TSH<10 mIu/L ) and SCH 2 group (TSH≥10 mIu/L) .Another 42 out‐patients (TSH≤4.12 mIu/L) were selected as a control group .Lipids ,glucose ,insulin levels ,homeostasis model assessment‐β(HOMA‐β) ,and ho‐meostasis model assessment insulin resistance (HOMA‐IR) were measured and compared between groups .Results Compared with the control group ,the higher total cholesterol (TC) ,low density lipoprotein‐cholesterol (LDL‐C) levels (P<0.05) ,and elevated fasting serum insulin (FINS) and HOMA‐βlevels (P<0.05) were found in SCH 1 and SCH 2 groups .Elevated FINS level was discovered in SCH 2 group compared to SCH 1 group (P<0.05) .There was no significant difference in HOMA‐IR level between SCH 1 and the control group (P>0.05) ,but HOMA‐IR level in SCH 2 group was higher than that in the control group (P<0.05) .Conclusion The phenomenon of lipids abnormality ,hyperinsulinemia and insulin resistance are found in se‐nile SCH patients .Among these patients ,high TSH levels show a consistency with the severity of hyperinsulinemia and insulin resistance .
