福建医药杂志
福建醫藥雜誌
복건의약잡지
Fujian Medical Journal
2015年
5期
59-61
,共3页
子宫肿瘤%协同共刺激分子%sB7-H 3%表达%临床意义
子宮腫瘤%協同共刺激分子%sB7-H 3%錶達%臨床意義
자궁종류%협동공자격분자%sB7-H 3%표체%림상의의
synergistic co-stimulatory molecules%sB7-H3%cervical cancer%expression analysis%clinical significance
目的：研究协同共刺激分子B7‐H3在宫颈癌患者血清中的表达及其临床意义。方法用ELISA方法检测宫颈癌、宫颈上皮内瘤样病变（CIN ）、宫颈炎患者和健康志愿者血清中游离B7‐H3的表达水平，结合患者临床资料评估循环B7‐H3对宫颈癌患者的临床意义。结果宫颈癌患者血清中存在B7‐H3的可溶性形式———sB7‐H3，其表达水平在宫颈癌、CIN、宫颈炎、正常志愿者之间的差异有统计学意义（P＜0.0001）。宫颈癌患者sB7‐H3的表达水平分别较CIN、宫颈炎患者和正常志愿者显著升高（均 P＜0.05），而CIN患者sB7‐H3表达分别与宫颈炎患者、正常志愿者比较的差异无统计学意义（均 P＞0.05）。sB7‐H3高表达与宫颈癌临床分期、淋巴结转移和组织分化程度有关，而与年龄和组织学类型无关。结论宫颈癌患者血清中存在sB7‐H 3，其高表达提示宫颈癌患者预后较差。
目的：研究協同共刺激分子B7‐H3在宮頸癌患者血清中的錶達及其臨床意義。方法用ELISA方法檢測宮頸癌、宮頸上皮內瘤樣病變（CIN ）、宮頸炎患者和健康誌願者血清中遊離B7‐H3的錶達水平，結閤患者臨床資料評估循環B7‐H3對宮頸癌患者的臨床意義。結果宮頸癌患者血清中存在B7‐H3的可溶性形式———sB7‐H3，其錶達水平在宮頸癌、CIN、宮頸炎、正常誌願者之間的差異有統計學意義（P＜0.0001）。宮頸癌患者sB7‐H3的錶達水平分彆較CIN、宮頸炎患者和正常誌願者顯著升高（均 P＜0.05），而CIN患者sB7‐H3錶達分彆與宮頸炎患者、正常誌願者比較的差異無統計學意義（均 P＞0.05）。sB7‐H3高錶達與宮頸癌臨床分期、淋巴結轉移和組織分化程度有關，而與年齡和組織學類型無關。結論宮頸癌患者血清中存在sB7‐H 3，其高錶達提示宮頸癌患者預後較差。
목적：연구협동공자격분자B7‐H3재궁경암환자혈청중적표체급기림상의의。방법용ELISA방법검측궁경암、궁경상피내류양병변（CIN ）、궁경염환자화건강지원자혈청중유리B7‐H3적표체수평，결합환자림상자료평고순배B7‐H3대궁경암환자적림상의의。결과궁경암환자혈청중존재B7‐H3적가용성형식———sB7‐H3，기표체수평재궁경암、CIN、궁경염、정상지원자지간적차이유통계학의의（P＜0.0001）。궁경암환자sB7‐H3적표체수평분별교CIN、궁경염환자화정상지원자현저승고（균 P＜0.05），이CIN환자sB7‐H3표체분별여궁경염환자、정상지원자비교적차이무통계학의의（균 P＞0.05）。sB7‐H3고표체여궁경암림상분기、림파결전이화조직분화정도유관，이여년령화조직학류형무관。결론궁경암환자혈청중존재sB7‐H 3，기고표체제시궁경암환자예후교차。
Objective To explore the expression level and clinical significance of the co‐stimulatory molecule B7‐H3 in blood serum of cervical carcinoma patients .Methods The blood serum B7‐H3 expression was detected by using ELISA kits in cervical cancer , cervical intraepithelial neoplasia (CIN ) , cervicitis and healthy volunteers to evaluate their clinical significance by combining clinical characteristics .Results There was a soluble form of B7‐H3 (sB7‐H3) in the blood serum of cervical canc‐er .The level of sB7‐H3 expression in human cervical cancer was higher than that in CIN、cervicitis and healthy volunteers (P<0.0001) .But the level of sB7‐H3 expression in CIN had no statistical significance than that in cervicitis and healthy volunteers (P>0.05) .A high level of sB7‐H3 in patients with cervical cancer was found to be correlated with the differentiation degree , clinical stage and lymph node metastasis .There was unrelated with ages and histological types .Conclusion The existence of sB7‐H3 in the blood serum of cervical cancer was revealed .The high level of sB7‐H3 expression represented a poor prognosis of human cervical cancer .
