CAJ | 학술논문

目的：观察三硫化二砷对荷急性早幼粒细胞白血病（ APL）腹水瘤小鼠生存的影响。方法建立SCID小鼠NB4细胞腹水瘤模型。分组如下：治疗组给予三硫化二砷悬液腹腔内注射，隔天1次，共3次；对照组给予质量分数0.5%甲基纤维素溶液（阴性对照）或阿霉素（阳性对照）。结果 SCID小鼠接种NB4细胞后能够形成腹水且死于APL腹水瘤。三硫化二砷100μg·g-1组生存期为（24.05±3.54）d，比阴性对照组的（16.27±2.34）d显著延长（P<0.05）。结论三硫化二砷能够在SCID小鼠体内抑制NB4细胞增殖，延长荷APL腹水瘤小鼠的生存期。
목적：관찰삼류화이신대하급성조유립세포백혈병（ APL）복수류소서생존적영향。방법건립SCID소서NB4세포복수류모형。분조여하：치료조급여삼류화이신현액복강내주사，격천1차，공3차；대조조급여질량분수0.5%갑기섬유소용액（음성대조）혹아매소（양성대조）。결과 SCID소서접충NB4세포후능구형성복수차사우APL복수류。삼류화이신100μg·g-1조생존기위（24.05±3.54）d，비음성대조조적（16.27±2.34）d현저연장（P<0.05）。결론삼류화이신능구재SCID소서체내억제NB4세포증식，연장하APL복수류소서적생존기。
Objective To observe the effects of arsenic trisulfide on survival of mice bearing acute promyelocytic leukemia( APL)ascites. Methods The animal model of SCID mice with NB4 cell ascites was established. The mice were divided into groups:the mice in the therapeutic group were intraperitoneally administrated with arsenic trisulfide suspension every other day for 3 doses;the mice in the control group were intraperitoneally administrated with 0. 5% methylcellulosis as negative control or adriamycine as positive control. Results The SCID mice grew as-cites after inoculated with NB4 cells and died of APL ascites. The survival times of treated mice in the 100μg·g-1 arsenic trisulfide group were(24. 05 ± 3. 54)days and were(16. 27 ± 2. 34)days in the negative control group(P<0. 05). Conclusion Arsenic trisulfide inhibite the proliferation of NB4 cells in vivo,and increase the survival of mice bearing APL ascites.