CAJ | 학술논문

目的探讨CD151在肝门部胆管癌组织中的表达及其与临床病理特征和预后的关系。方法采用免疫组化S-P法检测38例肝门部胆管癌、11例胆管炎病变组织标本中CDl51的表达，并分析其与肝门部胆管癌临床病理特征和预后的关系。结果 CDl51在肝门部胆管癌组织中的表达高于胆管炎组织。肝门部胆管癌组织中CDl51的表达与其淋巴结转移、TNM分期和生存状况密切相关（ P<0.05）。结论 CD151在肝门部胆管癌组织中存在高表达，且其表达随疾病进展而升高，CD151的高表达也预示着肝门部胆管癌较差的预后，CD151的检测可用于肝门部胆管癌的预后评估和治疗指导。
목적탐토CD151재간문부담관암조직중적표체급기여림상병리특정화예후적관계。방법채용면역조화S-P법검측38례간문부담관암、11례담관염병변조직표본중CDl51적표체，병분석기여간문부담관암림상병리특정화예후적관계。결과 CDl51재간문부담관암조직중적표체고우담관염조직。간문부담관암조직중CDl51적표체여기림파결전이、TNM분기화생존상황밀절상관（ P<0.05）。결론 CD151재간문부담관암조직중존재고표체，차기표체수질병진전이승고，CD151적고표체야예시착간문부담관암교차적예후，CD151적검측가용우간문부담관암적예후평고화치료지도。
Objective To examine the correlations of CDl51 expression with clinicopathological characteristics and prognosis of hilar cholangicocarcinoma. Methods Immunohistochemistry S-P method was used to detect the CD151 expressions in the 38 specimens of hilar cholangicocarcinoma and 11 specimens of benign bile duct tissues,and the correlations of CDl51 expression with clinicopathological characteristics and prognosis of hilar cholangicocarcinoma were analyzed. Results The positive expression rate of CD151 in the hilar cholangicocarcinoma was higher than that in the benign bile duct tissues. The expression of CD151 was related with lymph node metastasis,TNM stage and progno-sis of hilar cholangicocarcinoma( P < 0. 05 ). Conclusion High expression of CD151 is observed in the hilar cholangicocarcinoma,and detection of CD151 may be the factor to predict tumor progression and prognosis of hilar cholangicocarcinoma.