CAJ | 학술논문

目的：检测GPC3和CD44v6在肝细胞癌组织中的表达，并探讨其在肝细胞癌鉴别诊断中的临床应用价值。方法采用免疫组化方法，检测38例肝细胞癌（高分化组、中分化组、低分化组）及癌旁肝硬化组织石蜡标本中GPC3蛋白和CD44v6蛋白的表达；分析两种蛋白表达的相关性。结果 GPC3和CD44v6蛋白在肝细胞癌中的表达阳性率（84．2％和84．2％）显著高于癌旁肝硬化组织（0％和0％）（P＜0．01）。肝细胞癌高分化组、中分化组、低分化组同癌旁肝硬化组比较差异均有显著性意义，P＜0．05。 GPC3与CD44v6在肝细胞癌组织中的表达呈正相关（r＝0．502，P＜0．001）。结论 GPC3联合CD44v6可能有助于肝细胞癌的鉴别诊断。
목적：검측GPC3화CD44v6재간세포암조직중적표체，병탐토기재간세포암감별진단중적림상응용개치。방법채용면역조화방법，검측38례간세포암（고분화조、중분화조、저분화조）급암방간경화조직석사표본중GPC3단백화CD44v6단백적표체；분석량충단백표체적상관성。결과 GPC3화CD44v6단백재간세포암중적표체양성솔（84．2％화84．2％）현저고우암방간경화조직（0％화0％）（P＜0．01）。간세포암고분화조、중분화조、저분화조동암방간경화조비교차이균유현저성의의，P＜0．05。 GPC3여CD44v6재간세포암조직중적표체정정상관（r＝0．502，P＜0．001）。결론 GPC3연합CD44v6가능유조우간세포암적감별진단。
Objective To investigate the expression and clinical significance of GPC3 and CD44v6 in hepatocellular carci-noma(HCC), and evaluating their clinical value in the process of HCC development.Methods The GPC3 and CD44v6 ex-pressions in HCC and the liver tissue adjacent to carcinoma of 38 cases were detected by immunohistochemistry.Results The positive expression frequency of GPC3 and CD44v6 protein in HCC tissue (84.2% and 84.2%) were significantly higher than that in the liver tissue adjacent to carcinoma (0%and 0%)(P<0.01).The GPC3 expression was correlated with the CD44v6 expression in HCC (r=0.502,P<0.001).Conclusion The combination detection of GPC3 and CD44v6 would be helpful to HCC diagnosis.