实验与检验医学
實驗與檢驗醫學
실험여검험의학
Experimental and Laboratory Medicine
2015年
5期
598-599,611
,共3页
葛熙%洪煜婧%赵枰
葛熙%洪煜婧%趙枰
갈희%홍욱청%조평
白血病%BMI1%免疫组化
白血病%BMI1%免疫組化
백혈병%BMI1%면역조화
Leukemia%BMI1%Immunohistochemistry
目的：探讨BMI-1蛋白在慢性粒细胞白血病各期中的表达及意义。方法采用免疫化学SP 法测定BMI-1蛋白在对照组及CML 各期中的表达。结果 BMI-1蛋白在CML-AP/BP 组的表达显著高于对照组和CML-CP组(P<0.05)，CML-CP 组和对照组比较差异无统计学意义(P>0.05)；BMI-1蛋白在CML-AP/BP 未缓解组明显高于缓解组(P<0.05)。结论 BMI-1蛋白在CML-AP/BP骨髓单个核细胞中高表达且与CML发生急变及预后相关。
目的：探討BMI-1蛋白在慢性粒細胞白血病各期中的錶達及意義。方法採用免疫化學SP 法測定BMI-1蛋白在對照組及CML 各期中的錶達。結果 BMI-1蛋白在CML-AP/BP 組的錶達顯著高于對照組和CML-CP組(P<0.05)，CML-CP 組和對照組比較差異無統計學意義(P>0.05)；BMI-1蛋白在CML-AP/BP 未緩解組明顯高于緩解組(P<0.05)。結論 BMI-1蛋白在CML-AP/BP骨髓單箇覈細胞中高錶達且與CML髮生急變及預後相關。
목적：탐토BMI-1단백재만성립세포백혈병각기중적표체급의의。방법채용면역화학SP 법측정BMI-1단백재대조조급CML 각기중적표체。결과 BMI-1단백재CML-AP/BP 조적표체현저고우대조조화CML-CP조(P<0.05)，CML-CP 조화대조조비교차이무통계학의의(P>0.05)；BMI-1단백재CML-AP/BP 미완해조명현고우완해조(P<0.05)。결론 BMI-1단백재CML-AP/BP골수단개핵세포중고표체차여CML발생급변급예후상관。
Objective To investigate the expression and significance of BMI-1 protein in control group and in different phas-es of CML. Method The immunohistochemical SP staining was used to detect expression of BMI-1 protein in control group and in different phases of CML. Result Expression of BMI-1 protein in CML-AP/BP group was significantly higher than that in con-trol group and that in CML-CP group(P<0.05),expression of BMI-1 protein in control group and CML-CP group had no significant difference (P>0.05). Expression of BMI-1 protein in no remission group was significantly higher than that in complete remission group (P<0.05). Conclusion The high expression of BMI-1 protein in CML bone marrow mononuclear cells plays an important role in CML blast crisis and prognosis.
