CAJ | 학술논문

目的：了解我市学龄前儿童乙型肝炎病毒(HBV)的感染水平及HBV疫苗免疫效果，为乙型肝炎的防控提供理论依据。方法对2015年1-3月在我院就诊的本市3～6岁儿童1432例，采用酶联免疫吸附试验(ELISA)检测血清中HBsAg、HBsAb、HBeAg、HBeAb、HBcAb，统计分析检验结果。结果本批儿童HBsAg阳性率为0.91%，HBsAb阳性率为65.71%，本批儿童血清学模式共有7种。HBsAg，HBsAb阳性率的性别差异无显著性。结论在新生儿免费乙肝疫苗计划下，我市儿童乙肝病毒感染率低，但是，即使全程接种HBV疫苗，仍有部分儿童不能够产生有效的保护性抗体。如何提高儿童免疫接种后HBsAb阳性率，从而有效地控制和减少儿童乙肝病毒的传播，是医务工作者的一项任务。
목적：료해아시학령전인동을형간염병독(HBV)적감염수평급HBV역묘면역효과，위을형간염적방공제공이론의거。방법대2015년1-3월재아원취진적본시3～6세인동1432례，채용매련면역흡부시험(ELISA)검측혈청중HBsAg、HBsAb、HBeAg、HBeAb、HBcAb，통계분석검험결과。결과본비인동HBsAg양성솔위0.91%，HBsAb양성솔위65.71%，본비인동혈청학모식공유7충。HBsAg，HBsAb양성솔적성별차이무현저성。결론재신생인면비을간역묘계화하，아시인동을간병독감염솔저，단시，즉사전정접충HBV역묘，잉유부분인동불능구산생유효적보호성항체。여하제고인동면역접충후HBsAb양성솔，종이유효지공제화감소인동을간병독적전파，시의무공작자적일항임무。
Objective To evaluate the immune effect of hepatitis B vaccine in preschool children, and provide a theoretical basis for the prevention and control of hepatitis B virus infection. Methods Serum HBsAg, HBsAb, HBeAg, HBeAb and HBcAb of 1432 children, whose age is 3 to 6 years old, were detected by enzyme linked immunosorbent assay (ELISA) method, and the results were analyzed. Results The positive rates of HBsAg and HBsAb were 0.91%and 65.71%, respectively. There was no sig-nificant gender difference in positive rate of HBsAg and HBsAb. Conclusions After free hepatitis B vaccination programs in newborns, hepatitis B virus infection rate of the children in Nanchang city is low, however, there are still some children fail to pro-duce effective protective antibodies. How to improve the positive rate of HBsAb in children, so as to effectively control and reduce the spread of HBV infection in children, is an important task for medical workers.