实验与检验医学
實驗與檢驗醫學
실험여검험의학
Experimental and Laboratory Medicine
2015年
5期
556-559
,共4页
肝细胞癌%LZTFL1%Integrinβ1%分化程度
肝細胞癌%LZTFL1%Integrinβ1%分化程度
간세포암%LZTFL1%Integrinβ1%분화정도
Hepaticellelar carcinoma%LZTFL1%Integrinβ1%Differentiation
目的：探讨肿瘤抑制因子亮氨酸拉链蛋白转录因子样1(Leucine Zipper Transcription Factor Like 1，LZTFL1)和黏附分子整合素β1(Integrinβ1)在肝细胞癌中的蛋白表达情况、临床意义及二者的关系。方法采用免疫组织化学SP法联合检测90例肝细胞癌组织和20例正常肝组织中LZTFL1和Integrinβ1的表达，分析二者与肝细胞癌患者临床病理参数的关系及二者的相关性。结果与正常肝组织相比，肝细胞癌组织中LZTFL1的表达显著降低，而Integrinβ1的表达显著升高；随着肝细胞癌分化程度的降低，LZTFL1阳性率逐渐下降，Integrinβ1阳性率逐渐升高，差异均有统计学意义(P＜0.05)。二者的表达与患者的年龄、性别无显著相关性(P＞0.05)。且LZTFL1与Integrinβ1的蛋白表达呈负性相关(r=-0.406，P=0.026＜0.05)。结论(1)LZTFL1、Integrinβ1均与肝细胞癌的侵袭转移密切相关；(2)LZTFL1可能通过调控Integrinβ1，参与肿瘤细胞的侵袭和转移。
目的：探討腫瘤抑製因子亮氨痠拉鏈蛋白轉錄因子樣1(Leucine Zipper Transcription Factor Like 1，LZTFL1)和黏附分子整閤素β1(Integrinβ1)在肝細胞癌中的蛋白錶達情況、臨床意義及二者的關繫。方法採用免疫組織化學SP法聯閤檢測90例肝細胞癌組織和20例正常肝組織中LZTFL1和Integrinβ1的錶達，分析二者與肝細胞癌患者臨床病理參數的關繫及二者的相關性。結果與正常肝組織相比，肝細胞癌組織中LZTFL1的錶達顯著降低，而Integrinβ1的錶達顯著升高；隨著肝細胞癌分化程度的降低，LZTFL1暘性率逐漸下降，Integrinβ1暘性率逐漸升高，差異均有統計學意義(P＜0.05)。二者的錶達與患者的年齡、性彆無顯著相關性(P＞0.05)。且LZTFL1與Integrinβ1的蛋白錶達呈負性相關(r=-0.406，P=0.026＜0.05)。結論(1)LZTFL1、Integrinβ1均與肝細胞癌的侵襲轉移密切相關；(2)LZTFL1可能通過調控Integrinβ1，參與腫瘤細胞的侵襲和轉移。
목적：탐토종류억제인자량안산랍련단백전록인자양1(Leucine Zipper Transcription Factor Like 1，LZTFL1)화점부분자정합소β1(Integrinβ1)재간세포암중적단백표체정황、림상의의급이자적관계。방법채용면역조직화학SP법연합검측90례간세포암조직화20례정상간조직중LZTFL1화Integrinβ1적표체，분석이자여간세포암환자림상병리삼수적관계급이자적상관성。결과여정상간조직상비，간세포암조직중LZTFL1적표체현저강저，이Integrinβ1적표체현저승고；수착간세포암분화정도적강저，LZTFL1양성솔축점하강，Integrinβ1양성솔축점승고，차이균유통계학의의(P＜0.05)。이자적표체여환자적년령、성별무현저상관성(P＞0.05)。차LZTFL1여Integrinβ1적단백표체정부성상관(r=-0.406，P=0.026＜0.05)。결론(1)LZTFL1、Integrinβ1균여간세포암적침습전이밀절상관；(2)LZTFL1가능통과조공Integrinβ1，삼여종류세포적침습화전이。
Objective To investigate the expression and significance of LZTFL1 and integrin beta1 in hepaticellelar carcino-ma (HCC) and their relationship. Methods the expressions of LZTFL1 and integrin β1 in 90 cases of HCC and 20 cases of nor-mal liver tissues were detected by immunohistochemistry. The relationship between the two proteins and clinicopathological param-eters of HCC was analyzed. Results Compared with the normal liver tissues, the expression of LZTFL1 in hepatic cell carcinoma was markedly decreased, however, the expression of integrin beta1 was increased significantly (P<0.05). As the degree of HCC dif-ferentiation reduced, LZTFL1 expression gradually declined, while integrin beta1 expression increased step by step (P<0.05). Both of the expression had no correlation with the patient's age and gender (P>0.05). And, the expression of LZTFL1 was negatively correlated with the expression of integrin beta1 in hepatic cell carcinoma(r=-0.406, P=0.026<0.05). Conclusions (1) Our results suggested that LZTFL1 and integrin beta1 were closely related to the invasion and metastasis of HCC. (2) LZTFL1 may be involved in the invasion and metastasis of HCC, by regulating the expression of integrin beta1.
