CAJ | 학술논문

目的：探讨南昌地区女性宫颈细胞中人乳头瘤病毒(HPV)感染及基因型分布情况，为该地区防治人乳头瘤病毒感染和宫颈癌提供更科学、可靠的临床数据。方法回顾性分析2014年1月至2015年6月在江西中医药大学附属医院妇科门诊就诊的患者2659例，收集宫颈组织脱落细胞标本，采用核酸扩增和导流杂交技术检测标本中21种型别HPV基因，统计分析患者HPV感染率和HPV基因分布。结果在2659例患者中，HPV阳性者有708例，感染率为26.60%；感染率最高的基因型别为HPV52型，占7.60%，其次为HPV16、58、39、81、53型；<20岁组感染率最高，总阳性率为66.67%；在708例HPV感染患者中，单一感染率为74.85%，二重感染率为19.07%，三重感染率为3.95%四重感染率为0.99%，四重以上感染率为1.13%，≥65岁组多重感染比率显著高于其他各年龄组(20.83%，P<0.05)。结论南昌地区女性宫颈细胞HPV感染率呈明显的区域性特征，感染率相对较高，且基因型以高危型52、16、58型感染居多。
목적：탐토남창지구녀성궁경세포중인유두류병독(HPV)감염급기인형분포정황，위해지구방치인유두류병독감염화궁경암제공경과학、가고적림상수거。방법회고성분석2014년1월지2015년6월재강서중의약대학부속의원부과문진취진적환자2659례，수집궁경조직탈락세포표본，채용핵산확증화도류잡교기술검측표본중21충형별HPV기인，통계분석환자HPV감염솔화HPV기인분포。결과재2659례환자중，HPV양성자유708례，감염솔위26.60%；감염솔최고적기인형별위HPV52형，점7.60%，기차위HPV16、58、39、81、53형；<20세조감염솔최고，총양성솔위66.67%；재708례HPV감염환자중，단일감염솔위74.85%，이중감염솔위19.07%，삼중감염솔위3.95%사중감염솔위0.99%，사중이상감염솔위1.13%，≥65세조다중감염비솔현저고우기타각년령조(20.83%，P<0.05)。결론남창지구녀성궁경세포HPV감염솔정명현적구역성특정，감염솔상대교고，차기인형이고위형52、16、58형감염거다。
Objective To explore the prevalence and genotypes distribution situation of human papillomavirus(HPV) infection in cervical cell samples among women in Nanchang region in order to provide more scientific and reliable clinical data for the pre-vention and treatment of HPV infection and cervical cancer. Methods A total of 2659 women were retrospectively analyzed, who were in the outpatient department of gynecology of the Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine from January 2014 to June 2015, whose cervical cell samples were collected and 21 types of HPV genotypes were detected by us-ing the nucleic acid amplification and reverse dot hybridization technology. The HPV infection rate and the HPV gene distribution were statistically analyzed. Results A total of 708 HPV positive samples were found in 2659 women (26.60%); HPV52 had the highest infection rate, accounting for 7.60%, following with HPV16,58,39,81,53;<20 age group had the highest infection rate, total positive rate accounting for 66.67%;of 708 positive patients, 74.85%were with single HPV genotype infection, 19.07%with dou-ble HPV genotype infection, 3.95%with triple HPV genotype infection, 0.99%with quadruple HPV genotype infection, and 1.13%with more than quadriad HPV genotype infection;the multiple infection rate of ≥65 age group was obviously higher than those of all other age groups (20.83%,P<0.05). Conclusion Women have relatively higher HPV infection rate in Nanchang region, and HPV subtypes, such as HPV52,16,58, are superior infection genotypes.