CAJ | 학술논문

目的：通过左西孟旦对顽固性心衰患者脑钠肽前体（ pro－BNP）、心脏彩超左室射血分数（ LVEF）及左室舒张末容积（ LVEDV）、室性心律失常、炎症因子的影响，来观察研究左西孟旦治疗顽固性心衰患者的效果及其可能的作用机制。方法筛选出顽固性心衰的患者80人，随机分成两组，分别给予左西孟旦和米力农治疗，治疗前后分别测pro－BNP，LVEF， LVEDV，室性心律失常的次数及高敏C反映蛋白（hs－CRP），肿瘤坏死因子－a（TNF－a）。结果与对照组相比，经左西孟旦治疗后患者的pro－BNP水平、室性心律失常的次数显著下降，两组间LVEDV下降值无明显差距，左西孟旦组LVEF显著升高，同时hs－CRP、TNF－a也显著下降。结论左西孟旦治疗顽固性心衰优于传统正性肌力药物。
목적：통과좌서맹단대완고성심쇠환자뇌납태전체（ pro－BNP）、심장채초좌실사혈분수（ LVEF）급좌실서장말용적（ LVEDV）、실성심률실상、염증인자적영향，래관찰연구좌서맹단치료완고성심쇠환자적효과급기가능적작용궤제。방법사선출완고성심쇠적환자80인，수궤분성량조，분별급여좌서맹단화미력농치료，치료전후분별측pro－BNP，LVEF， LVEDV，실성심률실상적차수급고민C반영단백（hs－CRP），종류배사인자－a（TNF－a）。결과여대조조상비，경좌서맹단치료후환자적pro－BNP수평、실성심률실상적차수현저하강，량조간LVEDV하강치무명현차거，좌서맹단조LVEF현저승고，동시hs－CRP、TNF－a야현저하강。결론좌서맹단치료완고성심쇠우우전통정성기력약물。
Objectives This study addressed to measure pro-brain natriuretic peptide(pro-BNP), left ventricular ejection frac-tion(LVEF), left ventricular end diastolic volume (LVEDV) and ventricular arrhythmia and inflammatory factor in patients with re-fractory heart failure , aims to observe the efficacy and action mechanism of Levosimendan .Methods Selected eighty patients with refractory heart failure , that divided into two groups randomly and received Levosimendan or Milrinone treatment respectively .Re-corded the dates of pro-BNP, LVEF, LVEDV,hs-CRP,TNF-a and times of ventricular arrhythmia at pretherapy and post-treatment. Results Compared with control group , the levels of pro-BNP and times of ventricular arrhythmia in Levosimendan group were sig-nificantly lower.The decrease of LVEDV in the two groups were no gap .The date of LVEF%was higher than that in the Levosimen-dan group.The hs-CRP,TNF-a in Levosimendan group were significantly lower .Conclusions Levosimendan is better in treating refractory heart failure than that of traditional positive inotropic drug .