CAJ | 학술논문

目的：观察黄芪联合川芎嗪加中药熏洗治疗糖尿病周围神经病变（ DPN）的疗效评价及神经传导速度传导的影响。方法将120例DPN患者随机分成中西医结合治疗组、西医治疗组、对照组，治疗4周（其中川芎嗪治疗2周）后观察三组患者治疗前后的临床疗效评价、神经传导速度的变化。结果各组治疗前后多伦多CSS评分、神经传导速度组内比较（ P＜0.05）；治疗后中西医结合治疗组多伦多CSS评分、神经传导速度与西药治疗组及对照组比较（ P＜0.05）；西医治疗组治疗后上述指标也有明显变化，和对照组相比（ P＜0.05）。结论黄芪联合川芎嗪加中药熏洗能明显增加神经传导速度，有效改善DPN症状及体征，提示该治疗方法能有效控制和延缓DPN的进一步发展，值得临床上广泛运用和借鉴。
목적：관찰황기연합천궁진가중약훈세치료당뇨병주위신경병변（ DPN）적료효평개급신경전도속도전도적영향。방법장120례DPN환자수궤분성중서의결합치료조、서의치료조、대조조，치료4주（기중천궁진치료2주）후관찰삼조환자치료전후적림상료효평개、신경전도속도적변화。결과각조치료전후다륜다CSS평분、신경전도속도조내비교（ P＜0.05）；치료후중서의결합치료조다륜다CSS평분、신경전도속도여서약치료조급대조조비교（ P＜0.05）；서의치료조치료후상술지표야유명현변화，화대조조상비（ P＜0.05）。결론황기연합천궁진가중약훈세능명현증가신경전도속도，유효개선DPN증상급체정，제시해치료방법능유효공제화연완DPN적진일보발전，치득림상상엄범운용화차감。
Objective To evaluate the effect of Astragalus membranaceus combined with ligustrazine in fumigation -washing therapy for diabetic peripheral neuropathy ( DPN) and its influence on nerve conduction velocity.Methods A total of 120 patients with DPN were randomly assigned to the group receiving combined treatment of traditional Chinese and western medicine , the group receiving treatment with Western medicine , and the control group.After a 4-week treatment ( treatment with ligustrazine lasted only 2 weeks ) , the clinical effects and the changes of nerve conduction velocity before and after the treatment in the three groups were evaluated .Results There were signifi-cant differences in Toronto CSS Scores and nerve conduction velocity before and after the treatment in each group ( P<0.05 ).In compari-son with the western medicine group and the control group , Toronto CSS Scores and nerve conduction velocity in the group receiving com -bined treatment of traditional Chinese and western medicine were significantly altered after the treatment ( P<0.05 ).Compared with the control group , the indicators mentioned above were also significantly changed in the western medicine group after the treatment ( P<0.05 ).Conclusion Fumigation-washing therapy with Astragalus membranaceus combined with ligustrazine is able to increase nerve conduction velocity significantly and effectively improve the symptoms and signs of patients with DPN.It is suggested that this therapeutic method may effectively control and postpone the development of DPN , and it is worth to be extensively learned and applied in clinic.