CAJ | 학술논문

目的：通过检测VEGF和COX－2在前列腺癌组织及前列腺增生组织中的表达情况，从而探讨两者与前列腺癌发生发展的关系。方法采用免疫组化SP方法检测前列腺癌组织及前列腺增生组织中两者的表达情况，比较两者在两种不同组织中的表达情况。结果前列腺癌组织中，VEGF的表达阳性率为64.00％（32／50），在前列腺增生组织中VEGF的表达阳性率为15.0％（3／20），VEGF在前列腺癌组织及前列腺增生组织中表达阳性率差异性显著（P＜0.05）；COX－2在前列腺癌组织中的表达阳性率为68.00％（34／50），在前列腺增生组织中的阳性表达率为20.00％（4／20），COX－2在前列腺癌组织及前列腺增生组织中表达阳性率差异性显著（ P＜0.05）；VEGF的表达水平与肿瘤的分化程度、临床分期密切相关；COX－2与肿瘤的临床分期相关，但是与分化程度无明显关系。结论 VEGF与COX－2与前列腺癌的发生及发展密切相关，通过检测VEGF与COX－2的表达水平预测前列腺癌患者的预后情况，为临床上治疗前列腺癌提供一定的理论根据，因此也可以为临床上对前列腺癌的后续治疗提供一定的指导方法。
목적：통과검측VEGF화COX－2재전렬선암조직급전렬선증생조직중적표체정황，종이탐토량자여전렬선암발생발전적관계。방법채용면역조화SP방법검측전렬선암조직급전렬선증생조직중량자적표체정황，비교량자재량충불동조직중적표체정황。결과전렬선암조직중，VEGF적표체양성솔위64.00％（32／50），재전렬선증생조직중VEGF적표체양성솔위15.0％（3／20），VEGF재전렬선암조직급전렬선증생조직중표체양성솔차이성현저（P＜0.05）；COX－2재전렬선암조직중적표체양성솔위68.00％（34／50），재전렬선증생조직중적양성표체솔위20.00％（4／20），COX－2재전렬선암조직급전렬선증생조직중표체양성솔차이성현저（ P＜0.05）；VEGF적표체수평여종류적분화정도、림상분기밀절상관；COX－2여종류적림상분기상관，단시여분화정도무명현관계。결론 VEGF여COX－2여전렬선암적발생급발전밀절상관，통과검측VEGF여COX－2적표체수평예측전렬선암환자적예후정황，위림상상치료전렬선암제공일정적이론근거，인차야가이위림상상대전렬선암적후속치료제공일정적지도방법。
Objective To detect VEGF and COX-2 in prostate cancer and benign prostatic hyperplasia tissues , and thereby to explore the relationship between the development of prostate cancer.Methods Immunohistochemical SP method was used to detect prostate cancer and benign prostatic hyperplasia tissue expression , and the expression of both was compared in the two different tissues.Results In pros-tate cancer, VEGF expression positive rate was 64.00% (32/50).In BPH tissue, VEGF expression positive rate was 15.0% (3/20).There was significantly difference in positive rate of VEGF expression in prostate cancer and benign prostatic hyperplasia tissue ( P<0.05).COX-2 in prostate cancer tissue expression was 68.00%(34/50).The positive expression in benign prostatic hyperplasia tis-sue was 20.00%(4/20).In COX-2 expression in prostate cancer and benign prostatic hyperplasia , the positive rate was significantly difference ( P<0.05 ).The expression of VEGF was closely related with tumor differentiation and TNM stage.COX-2 was correlated with the clinical stage of the tumor , but there was no significant relationship between the degrees of differentiation.Conclusion VEGF and COX-2 is closely related to the occurrence and development of prostate cancer by detecting the expression of VEGF and COX -2 in predic-ting the prognosis of patients with prostate cancer to provide theoretical basis for the clinical treatment of prostate cancer , and therefore it may provide some guidance methods of clinical follow -up treatment for prostate cancer.