CAJ | 학술논문

近年脑出血的干细胞治疗策略因其良好的前景吸引了越来越多基础和临床研究工作者的兴趣。临床前研究表明移植诸如胚胎干细胞、诱导多能干细胞、神经干细胞和间充质干细胞等均可获得不错的疗效，并揭示了脑出血后干细胞移植治疗起效的可能机制有细胞替代、神经营养与保护、促血管生成、免疫炎症反应调节等。尽管临床研究也表明干细胞治疗脑出血安全有效，但影响干细胞移植治疗的几大关键因素尚未确定，例如移植的细胞类型、细胞数量、移植时间、最佳给药途径、最佳受众人群以及如何追踪细胞等。本文根据最新研究成果就以上关键影响因素的研究进展作一综述，为后续研究提供有价值的参考。
근년뇌출혈적간세포치료책략인기량호적전경흡인료월래월다기출화림상연구공작자적흥취。림상전연구표명이식제여배태간세포、유도다능간세포、신경간세포화간충질간세포등균가획득불착적료효，병게시료뇌출혈후간세포이식치료기효적가능궤제유세포체대、신경영양여보호、촉혈관생성、면역염증반응조절등。진관림상연구야표명간세포치료뇌출혈안전유효，단영향간세포이식치료적궤대관건인소상미학정，례여이식적세포류형、세포수량、이식시간、최가급약도경、최가수음인군이급여하추종세포등。본문근거최신연구성과취이상관건영향인소적연구진전작일종술，위후속연구제공유개치적삼고。
In recent years, stem cell-based approaches have attracted more attention from scientists and clinicians due to their possible therapeutical effect on intracerebral hemorrhage(ICH). Preclincal studies have demonstrated that the beneifcial effects of stem cells on ICH. The stem cells include embryonic stem cells(ESCs), inducible pluripotent stem cells(iPSCs), neural stem cells (NSCs), and mesenchymal stem cell(MSCs). Their underlying mechanisms might be due to cell replacement, neurotrophic and neuroprotection, angiogenesis, and modulation on inlfammation and immune response. Although several clinical studies have shown the high efifciency and safety of stem cell in ICH management, some key factors such stem cell type, cell dose, time window, and optimal cell transplantation approach remain to be addressed. According to the latest researches, this paper summarizes the advances in terms of these factors to provide a valuable reference for future research.