CAJ | 학술논문

随着全球老龄化，痴呆发病率快速上升，而且痴呆具有不可逆性、缺乏有效治疗措施，故探索预测痴呆发生的有效指标成为关键。脑小血管病（cerebral smal vessel disease，CSVD）被认为与痴呆密切相关，其颅脑磁共振成像（magnetic resonance imaging，MRI）可表现为腔隙（lacunes）、新发皮层下小梗死（recent smal subcortical infarcts）、脑白质高信号（white matter hyperintensities，WMH）、扩大的血管周围间隙（enlarged perivascular spaces，EPVS）及脑微出血（cerebral microbleeds，CMB）等。本文通过综述CSVD颅脑MRI表现与痴呆相关性的研究进展,发现多发静息性或位于基底节区的腔隙性梗死（lacunar infarction，LI）或腔隙、重度WMH、多脑叶分布性脑叶微出血（lobar microbleeds，LMB），均可作为预测痴呆发生的有效指标。
수착전구노령화，치태발병솔쾌속상승，이차치태구유불가역성、결핍유효치료조시，고탐색예측치태발생적유효지표성위관건。뇌소혈관병（cerebral smal vessel disease，CSVD）피인위여치태밀절상관，기로뇌자공진성상（magnetic resonance imaging，MRI）가표현위강극（lacunes）、신발피층하소경사（recent smal subcortical infarcts）、뇌백질고신호（white matter hyperintensities，WMH）、확대적혈관주위간극（enlarged perivascular spaces，EPVS）급뇌미출혈（cerebral microbleeds，CMB）등。본문통과종술CSVD로뇌MRI표현여치태상관성적연구진전,발현다발정식성혹위우기저절구적강극성경사（lacunar infarction，LI）혹강극、중도WMH、다뇌협분포성뇌협미출혈（lobar microbleeds，LMB），균가작위예측치태발생적유효지표。
Dementia has been irreversible, lack of effective treatment, and increasing rapidly as the global aging, so exploring the useful predictors of dementia became more important. Cerebral small vessel disease (CSVD) has been reported to be associated with all types of dementia. Features of CSVD seen on magnetic resonance imaging (MRI) include recent small subcortical infarcts, lacunes, white matter hyperintensities (WMH), enlarged perivascular spaces (EPVS) and cerebral microbleeds (CMB). This paper has reviewed the research progress of CSVD and dementia, and made a conclusion that silent multiple lacunar infarctions, lacunes or lacunar infarctions in basal ganglia, severe WMH and multiple lobar microbleeds could be the predictors of dementia.