CAJ | 학술논문

系统性硬皮病（systemic sclerosis，SSc）是一种慢性多系统的结缔组织疾病，其发病机制复杂。目前，尚无一种特效的治疗方法能检测硬皮病的发展，常需要多个临床科室对患者进行综合治疗。近年来，大量的临床研究揭示硬皮病的发病机制涉及多种细胞和分子因素，这就为未来产生新的治疗方法提供了可能。该文主要对目前的治疗方法和最新进展进行综述。这些治疗方法根据他们不同的作用机制，如免疫调节、抗纤维化及血管扩张剂等进行分类，同时对每种治疗方法进行分析讨论。
계통성경피병（systemic sclerosis，SSc）시일충만성다계통적결체조직질병，기발병궤제복잡。목전，상무일충특효적치료방법능검측경피병적발전，상수요다개림상과실대환자진행종합치료。근년래，대량적림상연구게시경피병적발병궤제섭급다충세포화분자인소，저취위미래산생신적치료방법제공료가능。해문주요대목전적치료방법화최신진전진행종술。저사치료방법근거타문불동적작용궤제，여면역조절、항섬유화급혈관확장제등진행분류，동시대매충치료방법진행분석토론。
Scleroderma (systemic sclerosis, SSc) is a chronic, multisystem connective tissue disease with a complex pathogenesis. Till now there is no sole therapy with optimal beneficial effects on all aspects of the disease process. It usually requires interdisciplinary approach in individual patient management. Recently, Clinical research to unravel the pathogenesis of scleroderma has implicated multiple cellular and molecular factors that are potential targets for future therapy. The objective of this article is to provide an overview of the available treatments and recent advances in the therapy of Scleroderma. These therapies have been classified into categories according to their mode of action-immunomodulators, antifibrotic or vasodilators and each will be discussed individually.