医学理论与实践
醫學理論與實踐
의학이론여실천
The Journal of Medical Theory and Practice
2015年
19期
2579-2581
,共3页
纤溶酶%冠心病%白介素-35%白介素-6%转化生长因子-β1
纖溶酶%冠心病%白介素-35%白介素-6%轉化生長因子-β1
섬용매%관심병%백개소-35%백개소-6%전화생장인자-β1
Plasmin%Coronary heart disease%Interleukin-35%Interleukin-6%Transforming growth factor-β1
目的:探讨纤溶酶对不同类型冠心病患者白介素‐35(IL‐35)、白介素‐6(IL‐6)及转化生长因子‐β1(TGF‐β1)的影响及其临床意义。方法:将110例患者随机分为纤溶酶组与常规组各55例,采用夹心酶联免疫法(ELISA )测定血浆IL‐35、IL‐6及TGF‐β1水平。比较两组患者治疗前、后 IL‐35、TGF‐β1及 IL‐6水平变化。结果:治疗后纤组 IL‐35、TGF‐β1升高更明显,IL‐6降低更明显(P<0.05),差异有统计学意义;纤组中急性冠脉综合征亚组IL‐35、TGF‐β1升高较稳定型心绞痛亚组更明显(P<0.05),IL‐6降低较稳定型心绞痛亚组更明显(P<0.05)。结论:纤溶酶能升高IL‐35、T G F‐β1水平,降低IL‐6水平,对冠心病疗效确切,且能改善预后。
目的:探討纖溶酶對不同類型冠心病患者白介素‐35(IL‐35)、白介素‐6(IL‐6)及轉化生長因子‐β1(TGF‐β1)的影響及其臨床意義。方法:將110例患者隨機分為纖溶酶組與常規組各55例,採用夾心酶聯免疫法(ELISA )測定血漿IL‐35、IL‐6及TGF‐β1水平。比較兩組患者治療前、後 IL‐35、TGF‐β1及 IL‐6水平變化。結果:治療後纖組 IL‐35、TGF‐β1升高更明顯,IL‐6降低更明顯(P<0.05),差異有統計學意義;纖組中急性冠脈綜閤徵亞組IL‐35、TGF‐β1升高較穩定型心絞痛亞組更明顯(P<0.05),IL‐6降低較穩定型心絞痛亞組更明顯(P<0.05)。結論:纖溶酶能升高IL‐35、T G F‐β1水平,降低IL‐6水平,對冠心病療效確切,且能改善預後。
목적:탐토섬용매대불동류형관심병환자백개소‐35(IL‐35)、백개소‐6(IL‐6)급전화생장인자‐β1(TGF‐β1)적영향급기림상의의。방법:장110례환자수궤분위섬용매조여상규조각55례,채용협심매련면역법(ELISA )측정혈장IL‐35、IL‐6급TGF‐β1수평。비교량조환자치료전、후 IL‐35、TGF‐β1급 IL‐6수평변화。결과:치료후섬조 IL‐35、TGF‐β1승고경명현,IL‐6강저경명현(P<0.05),차이유통계학의의;섬조중급성관맥종합정아조IL‐35、TGF‐β1승고교은정형심교통아조경명현(P<0.05),IL‐6강저교은정형심교통아조경명현(P<0.05)。결론:섬용매능승고IL‐35、T G F‐β1수평,강저IL‐6수평,대관심병료효학절,차능개선예후。
Objective :Explore the fibrinolytic enzyme in patients with different types of coronary heart disease interleu‐kin‐35(IL‐35) ,interleukin‐6 (IL‐6) and transforming growth factor‐β1 (TGF‐β1 ) ,the influence of and its relationship with the prognosis of patients .Methods :110 patients were randomly divided into the fibrinolytic enzyme group and rou‐tine group ,55 patients with sandwich enzyme‐linked immunoassay (ELISA) determination of serum IL‐35 ,IL‐6 and TGF‐β1 level .Compare two groups before and after treatment in patients with IL‐35 ,TGF‐β1 and IL‐6 level changes . Results:Fiber group after treatment of IL‐35 ,TGF‐β1 higher more apparent ,IL‐6 reduced more significantly ( P<0.05) ,the difference was statistically significant ;Fiber group in acute coronary syndrome and IL‐35 ,TGF‐β1 increases relatively stable angina subgroup more obvious (P<0 .05) ,IL‐6 reduce relatively stable angina subgroup more obvious (P<0 .05).Conclusion:Fibrinolytic enzyme can increase anti‐inflammatory factor (IL‐35 ,TGF‐β1 ) levels ,lower levels of inflammatory factors (IL‐6) ,the curative effect is coronary heart disease ,and can significantly improve the progno‐sis .