医学理论与实践
醫學理論與實踐
의학이론여실천
The Journal of Medical Theory and Practice
2015年
19期
2589-2590,2609
,共3页
欧阳小予%陈建平%杨阳%刘桑燕
歐暘小予%陳建平%楊暘%劉桑燕
구양소여%진건평%양양%류상연
非酒精性脂肪肝%血管内皮生长因子%白介素-6%高敏C反应蛋白
非酒精性脂肪肝%血管內皮生長因子%白介素-6%高敏C反應蛋白
비주정성지방간%혈관내피생장인자%백개소-6%고민C반응단백
Nonalcoholic fatty liver disease%Vascular endothelial growth factor%Interleukin-6%High-sensitivity C-re-active protein
目的：探讨非酒精性脂肪性肝病（NAFLD）患者血清血管内皮生长因子（VEGF）与白介素‐6（IL‐6）、高敏C反应蛋白（hs‐CRP）、白细胞计数（WBC）的相关性。方法：选取2013年1月－2015年1月在我院明确诊断 NAFLD患者122例，同时选取同期门诊健康体检者108例作为研究对象，采用全自动生化检测仪检测相关生化指标，通过酶联免疫吸附试验（ELISA）检测血清中VEGF、IL‐6水平，免疫比浊法检测血清hs‐CRP水平。结果：与对照组比较，脂肪肝组在臀围、腰围、体质指数、收缩压、舒张压、丙氨酸氨基转氨酶、天门冬氨酸转氨酶、甘油三酯、总胆固醇、低密度脂蛋白、血糖、尿酸、同型半胱氨酸、WBC、hs‐CRP、VEGF、IL‐6等临床指标均明显升高，差异有统计学意义（P均＜0．01）；进一步Pearson相关分析提示脂肪肝组血清VEGF水平与IL‐6、hs‐CRP、WBC均呈正相关（r分别为0．602、0．698、0．713，均 P＜0．01）。结论：NAFLD患者血清VEGF水平明显升高，其水平与IL‐6、hs‐CRP、WBC等均呈正相关，细胞因子、炎症因子参与了N A FLD的发生发展。
目的：探討非酒精性脂肪性肝病（NAFLD）患者血清血管內皮生長因子（VEGF）與白介素‐6（IL‐6）、高敏C反應蛋白（hs‐CRP）、白細胞計數（WBC）的相關性。方法：選取2013年1月－2015年1月在我院明確診斷 NAFLD患者122例，同時選取同期門診健康體檢者108例作為研究對象，採用全自動生化檢測儀檢測相關生化指標，通過酶聯免疫吸附試驗（ELISA）檢測血清中VEGF、IL‐6水平，免疫比濁法檢測血清hs‐CRP水平。結果：與對照組比較，脂肪肝組在臀圍、腰圍、體質指數、收縮壓、舒張壓、丙氨痠氨基轉氨酶、天門鼕氨痠轉氨酶、甘油三酯、總膽固醇、低密度脂蛋白、血糖、尿痠、同型半胱氨痠、WBC、hs‐CRP、VEGF、IL‐6等臨床指標均明顯升高，差異有統計學意義（P均＜0．01）；進一步Pearson相關分析提示脂肪肝組血清VEGF水平與IL‐6、hs‐CRP、WBC均呈正相關（r分彆為0．602、0．698、0．713，均 P＜0．01）。結論：NAFLD患者血清VEGF水平明顯升高，其水平與IL‐6、hs‐CRP、WBC等均呈正相關，細胞因子、炎癥因子參與瞭N A FLD的髮生髮展。
목적：탐토비주정성지방성간병（NAFLD）환자혈청혈관내피생장인자（VEGF）여백개소‐6（IL‐6）、고민C반응단백（hs‐CRP）、백세포계수（WBC）적상관성。방법：선취2013년1월－2015년1월재아원명학진단 NAFLD환자122례，동시선취동기문진건강체검자108례작위연구대상，채용전자동생화검측의검측상관생화지표，통과매련면역흡부시험（ELISA）검측혈청중VEGF、IL‐6수평，면역비탁법검측혈청hs‐CRP수평。결과：여대조조비교，지방간조재둔위、요위、체질지수、수축압、서장압、병안산안기전안매、천문동안산전안매、감유삼지、총담고순、저밀도지단백、혈당、뇨산、동형반광안산、WBC、hs‐CRP、VEGF、IL‐6등림상지표균명현승고，차이유통계학의의（P균＜0．01）；진일보Pearson상관분석제시지방간조혈청VEGF수평여IL‐6、hs‐CRP、WBC균정정상관（r분별위0．602、0．698、0．713，균 P＜0．01）。결론：NAFLD환자혈청VEGF수평명현승고，기수평여IL‐6、hs‐CRP、WBC등균정정상관，세포인자、염증인자삼여료N A FLD적발생발전。
Objective :To investigate the correlation between vascular endothelial growth factor and interleukin‐6 ,high‐sensitivity C‐reactive protein ,white blood cells count in patients with Nonalcoholic fatty liver disease .Methods :Select the 122 patients with nonalcoholic fatty liver disease (fatty liver group) ,108 people with no fatty liver disease (normal control group) were chosen for the study .The related biochemical indices were detected with automatic biochemical an‐alyzer .The levels of serum VEGF and IL‐6 were measured by Enzyme‐linked immunosorbent experiment .The levels of serum hs‐CRP were measured by Immune turbidimetry .Results:The comparison of hip circumference(HC) ,waist circ‐umference(WC) ,body mass index(BMI) ,systolic blood pressure(SBP) ,diastolic blood pressure(DBP) ,alanine amin‐otransferase(ALT) ,aspartate aminotransferase(AST) ,total cholesterol(TG) ,triglycerides(TC) ,low density lipopro‐tein(LDL‐C) ,glucose(GLU) ,uric acid(UA) ,homocysteine(Hcy) ,white blood cells count (WBC) ,high‐sensitivity C‐reactive protein (hs‐CRP) ,vascular endothelial growth factor (VEGF) ,interleukin‐6(IL‐6) levels between fatty liver group and normal control group were higher in the fatty liver group than those of normal control group ,the difference were significant(all P<0 .01) .Pearson correlation analysis show that serum VEGF levels and IL‐6 ,hs‐CRP ,WBC were positively correlated in patients with nonalcoholic fatty liver disease (r=0 .602 ,0 .698 ,0 .713 ,all P<0 .01) .Conclusion:The levels of VEGF were significantly increased in nonalcoholic fatty liver disease ,it was positively correlated with IL‐6 ,hs‐CRP ,WBC ,suggesting that cytokines and inflammatory cytokines might play an important role in the patho‐genesis of nonalcoholic fatty liver disease .
