医学理论与实践
醫學理論與實踐
의학이론여실천
The Journal of Medical Theory and Practice
2015年
19期
2582-2583
,共2页
王春%吕高友%张沈洁%徐颖%李娟%黄丽
王春%呂高友%張瀋潔%徐穎%李娟%黃麗
왕춘%려고우%장침길%서영%리연%황려
肿瘤坏死因子-α%白细胞介素-6%C反应蛋白%胰岛素抵抗
腫瘤壞死因子-α%白細胞介素-6%C反應蛋白%胰島素牴抗
종류배사인자-α%백세포개소-6%C반응단백%이도소저항
TNF-α%IL-6%CRP%Insulin resistance
目的:探讨胰岛素抵抗与肿瘤坏死因子‐α(TNF‐α)、白细胞介素‐6(IL‐6)及C反应蛋白(CRP)之间的关系及意义。方法:选择2012年8月-2014年8月在我院内分泌科住院的共111例2型糖尿病患者,分别根据各自的体重指数(BMI)分为肥胖组(BMI>25)和正常体重组(BMI 18~25),各组分别测定血清空腹血糖(FBG)水平及空腹胰岛素(FINS)水平,应用放免法检测空腹血清TNF‐α、CRP及IL‐6的水平,并进行相关统计学分析。结果:肥胖组患者血清血糖、TNF‐α、CRP及IL‐6水平及 HOMA‐IR显著高于正常体重组,差异具有统计学意义(P<0.01);TNF‐α、CRP及IL‐6水平与 HOMA‐IR存在显著正相关(P<0.01)。结论:2型糖尿病患者 TNF‐α、CRP及IL‐6水平与 HOMA‐IR存在显著相关性,检测2型糖尿病患者TNF‐α、CRP及IL‐6水平可了解其炎性反应水平及胰岛素抵抗的发生情况。
目的:探討胰島素牴抗與腫瘤壞死因子‐α(TNF‐α)、白細胞介素‐6(IL‐6)及C反應蛋白(CRP)之間的關繫及意義。方法:選擇2012年8月-2014年8月在我院內分泌科住院的共111例2型糖尿病患者,分彆根據各自的體重指數(BMI)分為肥胖組(BMI>25)和正常體重組(BMI 18~25),各組分彆測定血清空腹血糖(FBG)水平及空腹胰島素(FINS)水平,應用放免法檢測空腹血清TNF‐α、CRP及IL‐6的水平,併進行相關統計學分析。結果:肥胖組患者血清血糖、TNF‐α、CRP及IL‐6水平及 HOMA‐IR顯著高于正常體重組,差異具有統計學意義(P<0.01);TNF‐α、CRP及IL‐6水平與 HOMA‐IR存在顯著正相關(P<0.01)。結論:2型糖尿病患者 TNF‐α、CRP及IL‐6水平與 HOMA‐IR存在顯著相關性,檢測2型糖尿病患者TNF‐α、CRP及IL‐6水平可瞭解其炎性反應水平及胰島素牴抗的髮生情況。
목적:탐토이도소저항여종류배사인자‐α(TNF‐α)、백세포개소‐6(IL‐6)급C반응단백(CRP)지간적관계급의의。방법:선택2012년8월-2014년8월재아원내분비과주원적공111례2형당뇨병환자,분별근거각자적체중지수(BMI)분위비반조(BMI>25)화정상체중조(BMI 18~25),각조분별측정혈청공복혈당(FBG)수평급공복이도소(FINS)수평,응용방면법검측공복혈청TNF‐α、CRP급IL‐6적수평,병진행상관통계학분석。결과:비반조환자혈청혈당、TNF‐α、CRP급IL‐6수평급 HOMA‐IR현저고우정상체중조,차이구유통계학의의(P<0.01);TNF‐α、CRP급IL‐6수평여 HOMA‐IR존재현저정상관(P<0.01)。결론:2형당뇨병환자 TNF‐α、CRP급IL‐6수평여 HOMA‐IR존재현저상관성,검측2형당뇨병환자TNF‐α、CRP급IL‐6수평가료해기염성반응수평급이도소저항적발생정황。
Objective :To study TNF‐α,IL‐6 ,CRP and Insulin Resistance(IR) in Type 2 diabetes and to explore the re‐lationship of them .Methods :A total 111 Type 2 diabetes patients visiting the department of endocrinology in our hospi‐tal from August 2012 to August 2014 were selected ,and divided into 2 groups according to the body mass index ,inclu‐ding the obesity group (BMI>25)and normal weight group (BMI 18~25) .The FBG ,FINS ,TNF‐α,IL‐6 ,CRP were measured and IR were calculated in all the research objects ,and to conduct statistical analysis .Results:The FBG , TNF‐α,IL‐6 ,CRP level and HOMA‐IR in the obesity group were higher than the normal weight group(P<0 .01) ,and HOMA‐IR were positive correlated with the TNF‐α,IL‐6 ,CRP level(P<0 .01) .Conclusion:The TNF‐α,IL‐6 ,CRP lev‐el and HOMA‐IR were found significantly correlation ,the inflammatory response and IR in Type 2 diabetes can be known by detecting the serum levels of TNF‐α,IL‐6 and CRP .