CAJ | 학술논문

目的：总结卡介苗接种致不良反应的临床特征与治疗方法。方法收集2005年9月—2014年11月至我科就诊，并确诊为卡介苗接种后皮肤出现不良反应的患儿23例，对其自然信息、就诊后检查及治疗方案使用SPSS16.0统计软件分析处理数据及随访。结果男女比例为1.09∶1，1～3个月最多见（52.2%）。以皮肤表现（结节、斑块、脓肿）为主（23例），其次为淋巴结异常反应（8例，占25%）。治疗上皮损仅予对症治疗，伴淋巴结持续增大者口服异烟肼及利福平联合治疗。皮损于2～4个月愈合并遗留瘢痕。结论多数卡介苗接种后皮肤不良反应可通过外用药物及密切随访得到有效控制。
목적：총결잡개묘접충치불량반응적림상특정여치료방법。방법수집2005년9월—2014년11월지아과취진，병학진위잡개묘접충후피부출현불량반응적환인23례，대기자연신식、취진후검사급치료방안사용SPSS16.0통계연건분석처리수거급수방。결과남녀비례위1.09∶1，1～3개월최다견（52.2%）。이피부표현（결절、반괴、농종）위주（23례），기차위림파결이상반응（8례，점25%）。치료상피손부여대증치료，반림파결지속증대자구복이연정급리복평연합치료。피손우2～4개월유합병유류반흔。결론다수잡개묘접충후피부불량반응가통과외용약물급밀절수방득도유효공제。
ObjectiveTo summarize the clinical characteristics and therapeutic schedule of bacillus Calmette-Guérin (BCG). MethodsThe general conditions, auxiliary examination and therapeutic schedule of 23 patients diagnosed as adverse reaction of BCG vaccination, from September 2005 to November 2014, were retrospectively analyzed by SPSS16.0 statistical software and followed up.ResultsThe male and female ratio is 1.09:1, and 52.2% of the patients were in the age group of 1 to 3 month. Skin lesions were the mainly performance (23 cases, 100%), followed by abnormal reactions of lymph nodes (8 cases, 25%). Symptomatic treatment was given to the patients only with the skin lesions, and the patients with continued lymphadenectasis had been given the combined treatment of isoniazid and rifampicine. The natural history of these lesions is the ulceration formation and scarring that developed after 2 to 4 months from vaccination.ConclusionThe adverse reaction of BCG vaccination need intervention and close outpatient follow-up.